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Volume 18
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10.3390/pharmaceutics18060723
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Article

Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis

by
Yasmim Vilarim Barbosa
1,2,*,
Maria Elaine Cristina Araruna
2,3,
Maria Lorenna Pessoa Fonsêca
2,3,
Francisco José Batista de Lima Júnior
2,4,
Cassiano Francisco Weege Nonaka
5,
Paulo César Dantas da Silva
6,
José Elizandro Batista de Oliveira
1,2,3,
Bruna Larissa Barbosa de Lira
2,3,
Thássia Borges Costa
2,3 and
Vanda Lucia dos Santos
1,2,3
1
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Campina Grande 58429-500, PB, Brazil
2
Laboratório de Ensaios Farmacológicos, Universidade Estadual da Paraíba, Campina Grande 58429-500, PB, Brazil
3
Departamento de Farmácia, Universidade Estadual da Paraíba, Campina Grande 58429-500, PB, Brazil
4
Centro Universitário Unifacisa, Campina Grande 58408-326, PB, Brazil
5
Departamento de Odontologia, Universidade Estadual da Paraíba, Campina Grande 58429-500, PB, Brazil
6
Laboratório de Avaliação e Desenvolvimento de Biomateriais do Nordeste (CertBio), Universidade Estadual da Paraíba, Campina Grande 58429-500, PB, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceutics 2026, 18(6), 723; https://doi.org/10.3390/pharmaceutics18060723
Submission received: 2 May 2026 / Revised: 7 June 2026 / Accepted: 8 June 2026 / Published: 11 June 2026
(This article belongs to the Section Drug Targeting and Design)
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Abstract

Background/Objectives: Inflammatory bowel diseases (IBD) are conditions of the gastrointestinal tract with treatments linked to side effects and relapses. Spondias mombin L. is a species with anti-inflammatory action, but there is little information in the literature about its application in the treatment of IBD. The aim of this study was to evaluate the intestinal anti-inflammatory activity of hydroalcoholic extract of Spondias mombin L. (HESm) in a rat model of ulcerative colitis (UC). Methods: Hydroalcoholic extract was obtained using the turboextraction technique, followed by identification of its major components using ultra-high performance liquid chromatography (UFLC). Intestinal anti-inflammatory activity was evaluated in an acute model of UC induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Groups received a vehicle, prednisolone (2 mg/kg), or HESm (125, 250 or 500 mg/kg) before and after UC induction. Ulcerated area, score, and intestinal weight/length ratio were analyzed. Histopathological analysis and the extract’s effect on the contractility of the intestinal segment were carried out. Results: UFLC identified the presence of quercetin, a flavonoid widely cited for the species. At doses of 125, 250, and 500 mg/kg, the extract reduced areas of injury by 86.82, 92.67, and 85.06%, respectively, compared to the control, in addition to reducing scores and weight/length ratio of the colons. Histopathological analysis confirmed the results. In contractility, the extract at the highest concentration tested reduced the response of the muscarinic agonist carbamylcholine to 53.7 ± 4.2% of control contraction. Conclusions: Results demonstrate the species’ ability to reduce injuries caused by colitis, suggesting its potential to contribute to the clinical management of IBD in the future.
Keywords: inflammatory bowel disease; Spondias mombin L.; ulcerative colitis inflammatory bowel disease; Spondias mombin L.; ulcerative colitis

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MDPI and ACS Style

Barbosa, Y.V.; Araruna, M.E.C.; Fonsêca, M.L.P.; de Lima Júnior, F.J.B.; Nonaka, C.F.W.; da Silva, P.C.D.; de Oliveira, J.E.B.; de Lira, B.L.B.; Costa, T.B.; dos Santos, V.L. Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis. Pharmaceutics 2026, 18, 723. https://doi.org/10.3390/pharmaceutics18060723

AMA Style

Barbosa YV, Araruna MEC, Fonsêca MLP, de Lima Júnior FJB, Nonaka CFW, da Silva PCD, de Oliveira JEB, de Lira BLB, Costa TB, dos Santos VL. Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis. Pharmaceutics. 2026; 18(6):723. https://doi.org/10.3390/pharmaceutics18060723

Chicago/Turabian Style

Barbosa, Yasmim Vilarim, Maria Elaine Cristina Araruna, Maria Lorenna Pessoa Fonsêca, Francisco José Batista de Lima Júnior, Cassiano Francisco Weege Nonaka, Paulo César Dantas da Silva, José Elizandro Batista de Oliveira, Bruna Larissa Barbosa de Lira, Thássia Borges Costa, and Vanda Lucia dos Santos. 2026. "Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis" Pharmaceutics 18, no. 6: 723. https://doi.org/10.3390/pharmaceutics18060723

APA Style

Barbosa, Y. V., Araruna, M. E. C., Fonsêca, M. L. P., de Lima Júnior, F. J. B., Nonaka, C. F. W., da Silva, P. C. D., de Oliveira, J. E. B., de Lira, B. L. B., Costa, T. B., & dos Santos, V. L. (2026). Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis. Pharmaceutics, 18(6), 723. https://doi.org/10.3390/pharmaceutics18060723

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