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Article

Trans-p-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis

by
Supreeya Tantipat
1,
Kongkiat Trisuwan
2,3,
Phraepakaporn Kunnaja
4,
Seewaboon Sireeratawong
5,6,
Surapol Natakankitkul
1,
Surasak Imiam
7 and
Sunee Chansakaow
1,6,*
1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
2
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
3
Center of Excellence for Innovation in Chemistry, Chiang Mai University, Chiang Mai 50200, Thailand
4
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
5
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
6
Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
7
Department of Thai Traditional Medicine, Phrapokklao Hospital, Chanthaburi 22000, Thailand
*
Author to whom correspondence should be addressed.
Pharmaceutics 2025, 17(7), 864; https://doi.org/10.3390/pharmaceutics17070864 (registering DOI)
Submission received: 20 April 2025 / Revised: 24 June 2025 / Accepted: 27 June 2025 / Published: 30 June 2025
(This article belongs to the Special Issue Natural Pharmaceuticals Focused on Anti-inflammatory Activities)

Abstract

Background/Objectives: Wannachawee recipe (WCR) has been listed in the Hospital Traditional Medicine Formulary and has been used as a Thai medicine to treat psoriasis in the Thai Traditional Medicine Clinic of Prapokklao Hospital since 2006. Previous reports have found that WCR demonstrates good results for the treatment of patients with psoriasis. Among 136 Thai psoriasis patients who received WCR, 92.80% responded well. Although WCR is effective, there is still a lack of scientific data, especially relating to the bioactive compound in WCR. Therefore, this study aims to evaluate the phytochemicals in WCR via bioassay-guided isolation. Methods: In this study, the WCR was extracted via decoction with water, in a process based on traditional Thai medicine. The water extract was concentrated and dried using a spray dryer. The crude water extract was isolated using the partition technique with organic solvents, namely petroleum ether and ethyl acetate. These fractions were then separated and tested for anti-inflammatory activity using the bioassay-guided fractionation method. Results: Two particular types of pro-inflammatory cytokines are involved in inflammation and are among the factors that cause psoriasis—TNF-α and IL-6. Thus, we evaluated the isolated samples in terms of anti-inflammatory activity. The isolation resulted in two pure compounds—p-coumaryl aldehyde and trans-p-coumaryl alcohol. In the efficacy test of the isolated compounds, compared to the standard indomethacin at the same concentration of 12.5 ug/mL, trans-p-coumaryl alcohol was found to have the best efficacy, inhibiting TNF-α by 29.28% and IL-6 by 36.75%, with the standard compound showing inhibitions rates of 15.80% for TNF-α and 27.44% for IL-6. Conclusions: This study is the first report to identify the bioactive compound of WCR as trans-p-coumaryl alcohol or 4-hydroxycinnamyl alcohol.
Keywords: Wannachawee recipe; psoriasis; anti-inflammatory activity; p-coumaryl aldehyde; trans-p-coumaryl alcohol Wannachawee recipe; psoriasis; anti-inflammatory activity; p-coumaryl aldehyde; trans-p-coumaryl alcohol

Share and Cite

MDPI and ACS Style

Tantipat, S.; Trisuwan, K.; Kunnaja, P.; Sireeratawong, S.; Natakankitkul, S.; Imiam, S.; Chansakaow, S. Trans-p-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis. Pharmaceutics 2025, 17, 864. https://doi.org/10.3390/pharmaceutics17070864

AMA Style

Tantipat S, Trisuwan K, Kunnaja P, Sireeratawong S, Natakankitkul S, Imiam S, Chansakaow S. Trans-p-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis. Pharmaceutics. 2025; 17(7):864. https://doi.org/10.3390/pharmaceutics17070864

Chicago/Turabian Style

Tantipat, Supreeya, Kongkiat Trisuwan, Phraepakaporn Kunnaja, Seewaboon Sireeratawong, Surapol Natakankitkul, Surasak Imiam, and Sunee Chansakaow. 2025. "Trans-p-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis" Pharmaceutics 17, no. 7: 864. https://doi.org/10.3390/pharmaceutics17070864

APA Style

Tantipat, S., Trisuwan, K., Kunnaja, P., Sireeratawong, S., Natakankitkul, S., Imiam, S., & Chansakaow, S. (2025). Trans-p-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis. Pharmaceutics, 17(7), 864. https://doi.org/10.3390/pharmaceutics17070864

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