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Review

MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects

1
Department of Nephrology, Dongguan Traditional Chinese Medicine Hospital, Dongguan 523000, China
2
Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China
3
School of Materials and Environmental Engineering, Shenzhen Polytechnic University, Shenzhen 518055, China
4
Materials Electrochemistry Laboratory, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2024, 16(6), 793; https://doi.org/10.3390/pharmaceutics16060793
Submission received: 30 April 2024 / Revised: 3 June 2024 / Accepted: 4 June 2024 / Published: 11 June 2024
(This article belongs to the Section Drug Delivery and Controlled Release)

Abstract

Kidney diseases are important diseases that affect human health worldwide. According to the 2020 World Health Organization (WHO) report, kidney diseases have become the top 10 causes of death. Strengthening the prevention, primary diagnosis, and action of kidney-related diseases is of great significance in maintaining human health and improving the quality of life. It is increasingly challenging to address clinical needs with the present technologies for diagnosing and treating renal illness. Fortunately, metal-organic frameworks (MOFs) have shown great promise in the diagnosis and treatment of kidney diseases. This review summarizes the research progress of MOFs in the diagnosis and treatment of renal disease in recent years. Firstly, we introduce the basic structure and properties of MOFs. Secondly, we focus on the utilization of MOFs in the diagnosis and treatment of kidney diseases. In the diagnosis of kidney disease, MOFs are usually designed as biosensors to detect biomarkers related to kidney disease. In the treatment of kidney disease, MOFs can not only be used as an effective adsorbent for uremic toxins during hemodialysis but also as a precise treatment of intelligent drug delivery carriers. They can also be combined with nano-chelation technology to solve the problem of the imbalance of trace elements in kidney disease. Finally, we describe the current challenges and prospects of MOFs in the diagnosis and treatment of kidney diseases.
Keywords: kidney diseases; MOF; diagnosis kidney diseases; MOF; diagnosis

Share and Cite

MDPI and ACS Style

Deng, L.-E.; Guo, M.; Deng, Y.; Pan, Y.; Wang, X.; Maduraiveeran, G.; Liu, J.; Lu, C. MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects. Pharmaceutics 2024, 16, 793. https://doi.org/10.3390/pharmaceutics16060793

AMA Style

Deng L-E, Guo M, Deng Y, Pan Y, Wang X, Maduraiveeran G, Liu J, Lu C. MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects. Pharmaceutics. 2024; 16(6):793. https://doi.org/10.3390/pharmaceutics16060793

Chicago/Turabian Style

Deng, Li-Er, Manli Guo, Yijun Deng, Ying Pan, Xiaoxiong Wang, Govindhan Maduraiveeran, Jianqiang Liu, and Chengyu Lu. 2024. "MOF-Based Platform for Kidney Diseases: Advances, Challenges, and Prospects" Pharmaceutics 16, no. 6: 793. https://doi.org/10.3390/pharmaceutics16060793

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