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Volume 16
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Article

Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes

by
Vittoria Carrabs
1,2,3,
Maria Isabel Guillén
2,3,
María Luisa Ferrándiz
2,
María José Alcaraz
2,
Fabio Ferrini
1,
Rachele Agostini
1,
Michele Guescini
1,
Carmela Fimognari
4,
Italo Capparucci
1,
Elena Barbieri
1 and
Piero Sestili
1,*
1
Dipartimento di Scienze Biomolecolari, University of Urbino Carlo Bo, 61029 Urbino, Italy
2
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46010 Valencia, Spain
3
Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, 46115 Valencia, Spain
4
Dipartimento di Scienze per la Qualità della Vita, Università degli Studi di Bologna, C.so d’Augusto 237, 47921 Rimini, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2024, 16(11), 1386; https://doi.org/10.3390/pharmaceutics16111386
Submission received: 29 August 2024 / Revised: 24 October 2024 / Accepted: 25 October 2024 / Published: 28 October 2024
(This article belongs to the Special Issue Hyaluronic Acid for Medical Applications)
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Abstract

Background/Objectives: Osteoarthritis (OA) is the most common joint disease in the adult population. OA is the result of multiple mechanisms leading to inflammation and the degradation of the cartilage. A complex series of etiological actors have been identified so far, including extracellular vesicles (EVs). The EV content of the synovial fluid (SF) can release inflammatory mediators that enhance OA progression. An intra-articular viscosupplementation of high-MW hyaluronic acid (HyA) constitutes the first-line conservative treatment for OA. Although attractive for the potential pharmacological implications, the possibility that HyA may interact with EVs in the context of OA has not yet been specifically investigated; therefore, the present study aimed to fill this gap. Methods: We studied the effect of a HyA preparation (a blend of crosslinked and linear polymers, CLHyA) on the relevant inflammatory markers in chondrocytes (HC cells or primary chondrocytes isolated from patients with advanced OA) exposed to the EVs collected from IL-1β-stimulated THP-1 human monocytes (EVs+). Results: EVs+ caused specific inflammatory responses in chondrocytes that could be prevented by coincubation with CLHyA. This anti-inflammatory activity is likely dependent on the direct binding of CLHyA to CD44 receptors highly expressed in EVs+ and on the subsequent hindrance to EVs+ diffusion and docking to target cells. Conclusions: On the whole, the tight interactions identified herein between HMW HyA and EVs+ represent a novel, pharmacologically exploitable mechanism potentially relevant in the context of OA treatment.
Keywords: osteoarthritis; hyaluronic acid; extracellular vesicles; inflammation; infiltrative therapy; pathophysiology osteoarthritis; hyaluronic acid; extracellular vesicles; inflammation; infiltrative therapy; pathophysiology

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MDPI and ACS Style

Carrabs, V.; Guillén, M.I.; Ferrándiz, M.L.; Alcaraz, M.J.; Ferrini, F.; Agostini, R.; Guescini, M.; Fimognari, C.; Capparucci, I.; Barbieri, E.; et al. Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes. Pharmaceutics 2024, 16, 1386. https://doi.org/10.3390/pharmaceutics16111386

AMA Style

Carrabs V, Guillén MI, Ferrándiz ML, Alcaraz MJ, Ferrini F, Agostini R, Guescini M, Fimognari C, Capparucci I, Barbieri E, et al. Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes. Pharmaceutics. 2024; 16(11):1386. https://doi.org/10.3390/pharmaceutics16111386

Chicago/Turabian Style

Carrabs, Vittoria, Maria Isabel Guillén, María Luisa Ferrándiz, María José Alcaraz, Fabio Ferrini, Rachele Agostini, Michele Guescini, Carmela Fimognari, Italo Capparucci, Elena Barbieri, and et al. 2024. "Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes" Pharmaceutics 16, no. 11: 1386. https://doi.org/10.3390/pharmaceutics16111386

APA Style

Carrabs, V., Guillén, M. I., Ferrándiz, M. L., Alcaraz, M. J., Ferrini, F., Agostini, R., Guescini, M., Fimognari, C., Capparucci, I., Barbieri, E., & Sestili, P. (2024). Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes. Pharmaceutics, 16(11), 1386. https://doi.org/10.3390/pharmaceutics16111386

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