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Pharmaceutics
Volume 15
Issue 2
10.3390/pharmaceutics15020473
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Article
Peer-Review Record

Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer

Pharmaceutics 2023, 15(2), 473; https://doi.org/10.3390/pharmaceutics15020473
by Yu-Hsuan Liu 1,†, Ling-Chun Chen 2,†, Wen-Ting Cheng 2,†, Pu-Sheng Wei 1, Chien-Ming Hsieh 1, Ming-Thau Sheu 1, Shyr-Yi Lin 3,4, Hsiu-O Ho 1,* and Hong-Liang Lin 5,*
Reviewer 1:
Tarun K. Mandal
Reviewer 2: Anonymous
Pharmaceutics 2023, 15(2), 473; https://doi.org/10.3390/pharmaceutics15020473
Submission received: 11 November 2022 / Revised: 16 December 2022 / Accepted: 20 January 2023 / Published: 31 January 2023
(This article belongs to the Special Issue Recent Advances in Oral Solid Dosages)

Round 1

Reviewer 1 Report

The dissolution experiment is problematic. USP dissolution is a paddle method, not designed for dissolution of nanoemulsion. Cremophor EL is not appropriate for nanoemulsion formulation. The amount of drug in each batch is 10 mg/1 g total material. This drug content is too low to have any potential effect. The dissolution figure 1A legends need to be corrected. The authors simply collected 3 mL dissolution samples from the 500 mL total medium and analyzed. How can you confirm that the drug was in the solution form? Overall, the dissolution method is inappropriate to study drug releae from nanoemulsion.  

Author Response

please see the attached file.

Author Response File: Author Response.docx

Reviewer 2 Report

Submission requires revision. PDF attached.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

The authors carefully addressed the comments. Provided additional data and tables as requested. Hence, the manuscript is acceptable in its current form. 

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