Review Reports
- Yu-Hsuan Liu1,†,
- Ling-Chun Chen2,† and
- Wen-Ting Cheng2,†
- et al.
Reviewer 1: Tarun K. Mandal Reviewer 2: Anonymous
Round 1
Reviewer 1 Report
The dissolution experiment is problematic. USP dissolution is a paddle method, not designed for dissolution of nanoemulsion. Cremophor EL is not appropriate for nanoemulsion formulation. The amount of drug in each batch is 10 mg/1 g total material. This drug content is too low to have any potential effect. The dissolution figure 1A legends need to be corrected. The authors simply collected 3 mL dissolution samples from the 500 mL total medium and analyzed. How can you confirm that the drug was in the solution form? Overall, the dissolution method is inappropriate to study drug releae from nanoemulsion.
Author Response
please see the attached file.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Submission requires revision. PDF attached.
Comments for author File: 
Comments.pdf
Author Response
Please see the attachment.
Author Response File: Author Response.docx
Round 2
Reviewer 2 Report
The authors carefully addressed the comments. Provided additional data and tables as requested. Hence, the manuscript is acceptable in its current form.