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Pharmaceutics
Volume 15
Issue 1
10.3390/pharmaceutics15010169
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Peer-Review Record

Demonstrating Biological Fate of Nanoparticle-Loaded Dissolving Microneedles with Aggregation-Caused Quenching Probes: Influence of Application Sites

Pharmaceutics 2023, 15(1), 169; https://doi.org/10.3390/pharmaceutics15010169
by Yanping Fu 1, Chaonan Shi 1, Xiaodie Li 1, Ting Wen 2, Qiaoli Wu 3, Antian Zhang 1, Ping Hu 1, Chuanbin Wu 1, Xin Pan 2, Zhengwei Huang 1,* and Guilan Quan 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Pharmaceutics 2023, 15(1), 169; https://doi.org/10.3390/pharmaceutics15010169
Submission received: 27 November 2022 / Revised: 23 December 2022 / Accepted: 30 December 2022 / Published: 3 January 2023
(This article belongs to the Special Issue Recent Advances in Microneedle-Mediated Drug Delivery)

Round 1

Reviewer 1 Report


Comments for author File: Comments.docx

Author Response

We sincerely thank the reviewer's constructive comments. We have responded to the reviewer's comments point-by-point, and we have carefully revised the manuscript. Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript by Fu et al., titled “Demonstrating biological fate of nanoparticle-loaded dissolving microneedles with aggregation-caused quenching probes: Influence of application sites” is describing the impact of different skin sites on the transdermal diffusion of nanocarriers-loaded into integration of dissolving microneedles (NC-loaded DMNs). The authors claimed that the results showed different transdermal diffusion rates at different skin sites. The current work is important and provides new insights about choosing proper administration sites for microneedles. Overall manuscript is well written. Therefore, I recommend publication in Pharmaceutics after addressing the following points.

-          Some results lack statistical analysis. Please consider statistical analysis for figures 2f and figure 4e.

 

-          Nothing was mentioned about the toxicity of the prepared nanoparticles and DMNs. Please comment if they are safe to use.

Author Response

We sincerely thank the reviewer's constructive comments. We have responded to the reviewer's comments point-by-point, and we have carefully revised the manuscript. Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

I found the authors have addressed all the queries raised by the reviewer. Now it can be accepted for publication in the present format.

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