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Pharmaceutics
Volume 15
Issue 1
10.3390/pharmaceutics15010138
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Article
Peer-Review Record

The Effectiveness of a Bioactive Healing Abutment as a Local Drug Delivery System to Impact Peri-Implant Mucositis: A Prospective Case Series Study

Pharmaceutics 2023, 15(1), 138; https://doi.org/10.3390/pharmaceutics15010138
by Piotr Wychowański 1,2,*, Maciej Nowak 3, Andrzej Miskiewicz 3, Tadeusz Morawiec 4, Jarosław Woliński 5, Zbigniew Kucharski 6, Pier Carmine Passarelli 1, Alina Bodnarenko 7 and Michele Antonio Lopez 1,8
Reviewer 2: Anonymous
Pharmaceutics 2023, 15(1), 138; https://doi.org/10.3390/pharmaceutics15010138
Submission received: 10 November 2022 / Revised: 17 December 2022 / Accepted: 21 December 2022 / Published: 30 December 2022
(This article belongs to the Section Drug Delivery and Controlled Release)

Round 1

Reviewer 1 Report

The manuscript shows promising antibacterial effects of a Bioactive Healing Abutment against periodontal pathogens. Therefore, I recommend this article for publication after considering the following modifications.

  1. Figure 1, please increase the font sizes in blue boxes to increase the understanding.
  2. Swelling and redness decreased in patients after having BHA coated with Clindamycin. Was this effect because of the anti-inflammatory properties of Clindamycin, or was there a reduced bacterial number that led to a decrease in these inflammatory signs?
  3. Line 352-354, the authors report an increase in P. gingivalis in three patients despite having BHA. What was reason behind an increase in bacterial number? Was there any role of food behind this? Hopefully, there was a controlled release of Clindamycin from BHA in this situation.
  4. Line 353, remove this before the pathogen.
  5. Authors are advised to provide a general recommendation about the use of BHA. Considering their benefits and antibacterial activities, should BHA be routinely applied in patients?
  6. BHA did not show strong effect against some bacteria, do authors suggest to include a combination of antibiotics in BHA instead of using a single antibiotic?
  7. Please make references, 5,11,13,31, and 32 similar to other references.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Manuscript of considerable interest for the dental sector, a major revision is required before evaluating a possible publication

 

Abstract, highlight statistically significant data

 

Few keywords: add specific ones

 

Introduction: how does the oral microbiota change in the implant patient? Add reference from Prof Scribante

10.3390/app12073250

Materials and methods: how was the sample size calculated?

 

Results: very confusing, highlight statistically significant data

 

Discussion: Add proactive action using natural substances to reduce the incidence of pathogenic microorganisms as future goals

 

10.3390/microorganisms10040675

 

Conclusion; add proactive action

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

the manuscript was properly revised based on the comments that were suggested in the first session

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