Next Article in Journal
Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung
Next Article in Special Issue
Biosynthetic Silver Nanoparticles Inhibit the Malignant Behavior of Gastric Cancer Cells and Enhance the Therapeutic Effect of 5-Fluorouracil by Promoting Intracellular ROS Generation and Apoptosis
Previous Article in Journal
Modeling the Probability of HIV Infection over Time in High-Risk Seronegative Participants Receiving Placebo in Five Randomized Double-Blind Placebo-Controlled HIV Pre-Exposure Prophylaxis Trials: A Patient-Level Pooled Analysis
Previous Article in Special Issue
pH Sensitive Pluronic Acid/Agarose-Hydrogels as Controlled Drug Delivery Carriers: Design, Characterization and Toxicity Evaluation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 14
Issue 9
10.3390/pharmaceutics14091802
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy

by
Zhaoming Ma
1,2,
Xuzhu Gao
1,
Faisal Raza
3,
Hajra Zafar
3,
Guanhong Huang
1,
Yunyun Yang
1,
Feng Shi
4,
Deqiang Wang
4,5,* and
Xia He
2,*
1
Department of Radiotherapy, The Second People’s Hospital of Lianyungang, Lianyungang 222023, China
2
Department of Radiation Oncology, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
3
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
4
Institute of Digestive Diseases, Jiangsu University, Zhenjiang 212001, China
5
Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2022, 14(9), 1802; https://doi.org/10.3390/pharmaceutics14091802
Submission received: 8 August 2022 / Accepted: 25 August 2022 / Published: 27 August 2022
(This article belongs to the Special Issue Nanocarriers for Drug Delivery and/or Gene Therapy in Cancer)
Browse Figures
Review Reports Versions Notes

Abstract

Oesophageal cancer is a malignant tumor with high morbidity and mortality. Surgical treatment, radiotherapy, and chemotherapy are the most common treatment methods for oesophageal cancer. However, traditional chemotherapy drugs have poor targeting performance and cause serious adverse drug reactions. In this study, a GSH-sensitive material, ATRA-SS-HA, was developed and self-assembled with curcumin, a natural polyphenol antitumor drug, into nanomicelles Cur@ATRA-SS-HA. The micelles had a suitable particle size, excellent drug loading, encapsulation rate, stability, biocompatibility, and stable release behaviour. In the tumor microenvironment, GSH induced disulfide bond rupture in Cur@ATRA-SS-HA and promoted the release of curcumin, improving tumor targeting. Following GSH-induced release, the curcumin IC50 value was significantly lower than that of free curcumin and better than that of 5-FU. In vivo pharmacokinetic experiments showed that the drug-loaded nanomicelles exhibited better metabolic behaviour than free drugs, which greatly increased the blood concentration of curcumin and increased the half-life of the drug. The design of the nanomicelle provides a novel clinical treatment for oesophageal cancer.
Keywords: oesophageal cancer; curcumin; nanomicelles; GSH responsive oesophageal cancer; curcumin; nanomicelles; GSH responsive

Share and Cite

MDPI and ACS Style

Ma, Z.; Gao, X.; Raza, F.; Zafar, H.; Huang, G.; Yang, Y.; Shi, F.; Wang, D.; He, X. Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy. Pharmaceutics 2022, 14, 1802. https://doi.org/10.3390/pharmaceutics14091802

AMA Style

Ma Z, Gao X, Raza F, Zafar H, Huang G, Yang Y, Shi F, Wang D, He X. Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy. Pharmaceutics. 2022; 14(9):1802. https://doi.org/10.3390/pharmaceutics14091802

Chicago/Turabian Style

Ma, Zhaoming, Xuzhu Gao, Faisal Raza, Hajra Zafar, Guanhong Huang, Yunyun Yang, Feng Shi, Deqiang Wang, and Xia He. 2022. "Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy" Pharmaceutics 14, no. 9: 1802. https://doi.org/10.3390/pharmaceutics14091802

APA Style

Ma, Z., Gao, X., Raza, F., Zafar, H., Huang, G., Yang, Y., Shi, F., Wang, D., & He, X. (2022). Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy. Pharmaceutics, 14(9), 1802. https://doi.org/10.3390/pharmaceutics14091802

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop