Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes

Cheng, Zesheng; Que, Haiying; Chen, Li; Sun, Qiu; Wei, Xiawei

doi:10.3390/pharmaceutics14071372

Open AccessReview

Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes

by

Zesheng Cheng

^†,

Haiying Que

^†

,

Li Chen

,

Qiu Sun

^* and

Xiawei Wei

^*

Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatricts, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Pharmaceutics 2022, 14(7), 1372; https://doi.org/10.3390/pharmaceutics14071372

Submission received: 21 April 2022 / Revised: 28 May 2022 / Accepted: 22 June 2022 / Published: 28 June 2022

(This article belongs to the Section Drug Delivery and Controlled Release)

Download

Browse Figures

Versions Notes

Abstract

The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, and immune regulation. The lymph nodes (LNs) are known as the primary sites of tumor metastasis and the metastatic LNs largely affected the prognosis of the patiens. A well-designed lymphatic-targeted system favors disease treatment as well as vaccination efficacy. In recent years, development of nanotechnologies and emerging biomaterials have gained increasing attention in developing lymph-node-targeted drug-delivery systems. By mimicking the endogenous macromolecules or lipid conjugates, lymph-node-targeted nanocarries hold potential for disease diagnosis and tumor therapy. This review gives an introduction to the physiological functions of LNs and the roles of LNs in diseases, followed by a review of typical lymph-node-targeted nanomaterial-based drug-delivery systems (e.g., liposomes, micelles, inorganic nanomaterials, hydrogel, and nanocapsules). Future perspectives and conclusions concerned with lymph-node-targeted drug-delivery systems are also provided.

Keywords: lymph node; drug-delivery system; targeted therapy; immunology; cancer

Share and Cite

MDPI and ACS Style

Cheng, Z.; Que, H.; Chen, L.; Sun, Q.; Wei, X. Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes. Pharmaceutics 2022, 14, 1372. https://doi.org/10.3390/pharmaceutics14071372

AMA Style

Cheng Z, Que H, Chen L, Sun Q, Wei X. Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes. Pharmaceutics. 2022; 14(7):1372. https://doi.org/10.3390/pharmaceutics14071372

Chicago/Turabian Style

Cheng, Zesheng, Haiying Que, Li Chen, Qiu Sun, and Xiawei Wei. 2022. "Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes" Pharmaceutics 14, no. 7: 1372. https://doi.org/10.3390/pharmaceutics14071372

APA Style

Cheng, Z., Que, H., Chen, L., Sun, Q., & Wei, X. (2022). Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes. Pharmaceutics, 14(7), 1372. https://doi.org/10.3390/pharmaceutics14071372

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI