Next Article in Journal
Developing Novel Hydroxypropyl-β-Cyclodextrin-Based Nanosponges as Carriers for Anticancer Hydrophobic Agents: Overcoming Limitations of Host–Guest Complexes in a Comparative Evaluation
Next Article in Special Issue
Co-Loading of Inorganic Nanoparticles and Natural Oil in the Electrospun Janus Nanofibers for a Synergetic Antibacterial Effect
Previous Article in Journal
Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed Crystallization and Fluidized Bed Processing
Previous Article in Special Issue
Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems
Article

Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies

1
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
2
National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania
3
Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 011061 Bucharest, Romania
4
Microbiology and Immunology Department, Faculty of Biology, Research Institute of the University of Bucharest, University of Bucharest, 060101 Bucharest, Romania
5
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1–7 Polizu Str., 011061 Bucharest, Romania
6
National Research Center for Food Safety, University Politehnica of Bucharest, 060042 Bucharest, Romania
7
Research Institute of the University of Bucharest—ICUB, 91–95 Spl. Independentei, 50567 Bucharest, Romania
8
Research & Development for Advanced Biotechnologies and Medical Devices, SC Sanimed International Impex SRL, 087040 Călugăreni, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Gregor Fuhrmann and Rita Sobral Santos
Pharmaceutics 2022, 14(5), 1057; https://doi.org/10.3390/pharmaceutics14051057
Received: 2 April 2022 / Revised: 10 May 2022 / Accepted: 11 May 2022 / Published: 14 May 2022
(This article belongs to the Special Issue Nanomaterials and Novel Biologics to Manage Bacterial Infections)
The current trend in antimicrobial-agent development focuses on the use of natural compounds that limit the toxicity of conventional drugs and provide a potential solution to the antimicrobial resistance crisis. Curcumin represents a natural bioactive compound with well-known antimicrobial, anticancer, and antioxidant properties. However, its hydrophobicity considerably limits the possibility of body administration. Therefore, dextran-coated iron oxide nanoparticles can be used as efficient drug-delivery supports that could overcome this limitation. The iron oxide nanoparticles were synthesized through the microwave-assisted hydrothermal method by varying the treatment parameters (pressure and reaction time). The nanoparticles were subsequently coated with dextran and used for the loading of curcumin (in various concentrations). The drug-delivery systems were characterized through X-ray diffraction (XRD) coupled with Rietveld refinement, transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), selected area electron diffraction (SAED), dynamic light scattering (DLS) and zeta potential, thermogravimetry and differential scanning calorimetry (TG-DSC), vibrating sample magnetometry (VSM), and UV-Vis spectrophotometry, as well as regarding their antimicrobial efficiency and biocompatibility using the appropriate assays. The results demonstrate a promising antimicrobial efficiency, as well as an increased possibility of controlling the properties of the resulted nanosystems. Thus, the present study represents an important step forward toward the development of highly efficient antimicrobial drug-delivery systems. View Full-Text
Keywords: iron oxide nanoparticles; microwave-assisted hydrothermal method; dextran; curcumin; antimicrobial therapy iron oxide nanoparticles; microwave-assisted hydrothermal method; dextran; curcumin; antimicrobial therapy
Show Figures

Figure 1

MDPI and ACS Style

Chircov, C.; Ștefan, R.-E.; Dolete, G.; Andrei, A.; Holban, A.M.; Oprea, O.-C.; Vasile, B.S.; Neacșu, I.A.; Tihăuan, B. Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies. Pharmaceutics 2022, 14, 1057. https://doi.org/10.3390/pharmaceutics14051057

AMA Style

Chircov C, Ștefan R-E, Dolete G, Andrei A, Holban AM, Oprea O-C, Vasile BS, Neacșu IA, Tihăuan B. Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies. Pharmaceutics. 2022; 14(5):1057. https://doi.org/10.3390/pharmaceutics14051057

Chicago/Turabian Style

Chircov, Cristina, Raluca-Elena Ștefan, Georgiana Dolete, Adriana Andrei, Alina M. Holban, Ovidiu-Cristian Oprea, Bogdan S. Vasile, Ionela A. Neacșu, and Bianca Tihăuan. 2022. "Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies" Pharmaceutics 14, no. 5: 1057. https://doi.org/10.3390/pharmaceutics14051057

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop