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Pharmaceutics
Volume 14
Issue 3
10.3390/pharmaceutics14030595
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Retraction of Pharmaceutics 2020, 12(2), 176.
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Retraction

RETRACTED: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

by
Laura Hellinen
1,
Heidi Hongisto
2,
Eva Ramsay
3,
Kai Kaarniranta
2,4,
Kati-Sisko Vellonen
1,
Heli Skottman
5 and
Marika Ruponen
1,*
1
School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70210 Kuopio, Finland
2
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland
3
Drug Research Programme, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland
4
Department of Ophthalmology, Kuopio University Hospital, P.O.Box 100, FI-70029 Kuopio, Finland
5
Faculty of Medicine and Health Technology, BioMediTech, Tampere University, 33520 Tampere, Finland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2022, 14(3), 595; https://doi.org/10.3390/pharmaceutics14030595
Submission received: 28 February 2022 / Accepted: 8 March 2022 / Published: 9 March 2022
Versions Notes
The published article [1] has been retracted due to data errors. During a review of the data, the authors found that the studied LEPI-1 cell line is not derived from the ARPE-19 RPE cell line of the human origin as described in the article but rather originates from the Madin-Darby canine (Canis familiaris) kidney cell line with the human MDR1 gene (MDCK-MDR1). This incorrect interpretation of the cell origin was a consequence of cell line cross-contamination and an error in characterization process.
The outcome and conclusions of the study were affected, so it was decided that a correction would not be appropriate, and the paper will therefore be retracted. We apologize for any inconvenience caused by the removal of this article.
To ensure the addition of only high quality scientific works to the field of scholarly publication, this article [1] is retracted and shall be marked accordingly. We apologize to the readers of Pharmaceutics.

Reference

  1. Hellinen, L.; Hongisto, H.; Ramsay, E.; Kaarniranta, K.; Vellonen, K.-S.; Skottman, H.; Ruponen, M. RETRACTED: Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176. [Google Scholar] [CrossRef] [PubMed]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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MDPI and ACS Style

Hellinen, L.; Hongisto, H.; Ramsay, E.; Kaarniranta, K.; Vellonen, K.-S.; Skottman, H.; Ruponen, M. RETRACTED: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176. Pharmaceutics 2022, 14, 595. https://doi.org/10.3390/pharmaceutics14030595

AMA Style

Hellinen L, Hongisto H, Ramsay E, Kaarniranta K, Vellonen K-S, Skottman H, Ruponen M. RETRACTED: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176. Pharmaceutics. 2022; 14(3):595. https://doi.org/10.3390/pharmaceutics14030595

Chicago/Turabian Style

Hellinen, Laura, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, and Marika Ruponen. 2022. "RETRACTED: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176" Pharmaceutics 14, no. 3: 595. https://doi.org/10.3390/pharmaceutics14030595

APA Style

Hellinen, L., Hongisto, H., Ramsay, E., Kaarniranta, K., Vellonen, K.-S., Skottman, H., & Ruponen, M. (2022). RETRACTED: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176. Pharmaceutics, 14(3), 595. https://doi.org/10.3390/pharmaceutics14030595

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