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Review

The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

1
School of Medicine and Health Sciences, Department of Nutrition, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain
2
SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Joseph Kost
Pharmaceutics 2022, 14(1), 101; https://doi.org/10.3390/pharmaceutics14010101
Received: 13 December 2021 / Revised: 27 December 2021 / Accepted: 29 December 2021 / Published: 2 January 2022
(This article belongs to the Special Issue The Role of Natural Products on Diabetes Mellitus Treatment)
The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed. View Full-Text
Keywords: diabetes mellitus; type 2; biological products; plants; antioxidants; therapeutics; natural products; phenols diabetes mellitus; type 2; biological products; plants; antioxidants; therapeutics; natural products; phenols
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MDPI and ACS Style

Vivó-Barrachina, L.; Rojas-Chacón, M.J.; Navarro-Salazar, R.; Belda-Sanchis, V.; Pérez-Murillo, J.; Peiró-Puig, A.; Herran-González, M.; Pérez-Bermejo, M. The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials. Pharmaceutics 2022, 14, 101. https://doi.org/10.3390/pharmaceutics14010101

AMA Style

Vivó-Barrachina L, Rojas-Chacón MJ, Navarro-Salazar R, Belda-Sanchis V, Pérez-Murillo J, Peiró-Puig A, Herran-González M, Pérez-Bermejo M. The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials. Pharmaceutics. 2022; 14(1):101. https://doi.org/10.3390/pharmaceutics14010101

Chicago/Turabian Style

Vivó-Barrachina, Lucía, María José Rojas-Chacón, Rocío Navarro-Salazar, Victoria Belda-Sanchis, Javier Pérez-Murillo, Alicia Peiró-Puig, Mariana Herran-González, and Marcelino Pérez-Bermejo. 2022. "The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials" Pharmaceutics 14, no. 1: 101. https://doi.org/10.3390/pharmaceutics14010101

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