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Article

Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection

1
Institute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA
2
Department of Physical and Colloid Chemistry, Gubkin University, Leninsky Pr. 65, 119991 Moscow, Russia
3
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Slawomir Kadlubowski and Gustavo H.C. Varca
Pharmaceutics 2021, 13(9), 1477; https://doi.org/10.3390/pharmaceutics13091477
Received: 22 July 2021 / Revised: 4 September 2021 / Accepted: 9 September 2021 / Published: 15 September 2021
(This article belongs to the Special Issue Nanogels and Nanoparticles for Selective Drug Delivery)
Topical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, and other agricultural livestock. The hair surface of mammals varies in hydrophobicity having a cortex surrounded by cuticles. Spontaneous 1–2 µm thick halloysite hair coverages on the semi-aquatic rodent capybara, non-aquatic rodent guinea pig, and farm goats were compared. The best coating was found for capybara due to the elevated 5 wt% wax content. As a result, we suggest hair pretreatment with diluted wax for enhanced nanoclay adsorption. The formation of a stable goat hair coverage with a 2–3 µm halloysite layer loaded with permethrin insecticide allowed for long-lasting anti-parasitic protection, enduring multiple rain wettings and washings. We expect that our technology will find applications in animal parasitosis protection and may be extended to prolonged human anti-lice treatment. View Full-Text
Keywords: hair surface engineering; topical drug administration; antiparasitic formulations; halloysite; self-assembly; capybara; guinea pig hair surface engineering; topical drug administration; antiparasitic formulations; halloysite; self-assembly; capybara; guinea pig
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MDPI and ACS Style

Rahman, N.; Scott, F.H.; Lvov, Y.; Stavitskaya, A.; Akhatova, F.; Konnova, S.; Fakhrullina, G.; Fakhrullin, R. Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection. Pharmaceutics 2021, 13, 1477. https://doi.org/10.3390/pharmaceutics13091477

AMA Style

Rahman N, Scott FH, Lvov Y, Stavitskaya A, Akhatova F, Konnova S, Fakhrullina G, Fakhrullin R. Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection. Pharmaceutics. 2021; 13(9):1477. https://doi.org/10.3390/pharmaceutics13091477

Chicago/Turabian Style

Rahman, Naureen, Faith H. Scott, Yuri Lvov, Anna Stavitskaya, Farida Akhatova, Svetlana Konnova, Gӧlnur Fakhrullina, and Rawil Fakhrullin. 2021. "Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection" Pharmaceutics 13, no. 9: 1477. https://doi.org/10.3390/pharmaceutics13091477

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