Next Article in Journal
A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy
Next Article in Special Issue
Impact of Powder Properties on the Rheological Behavior of Excipients
Previous Article in Journal
Studying the Complex Formation of Sulfonatocalix[4]naphthalene and Meloxicam towards Enhancing Its Solubility and Dissolution Performance
Previous Article in Special Issue
Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM
Article

Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression

1
Institute of Machine Tools and Production Technology (IWF), Technische Universität Braunschweig, Langer Kamp 19b, 38106 Braunschweig, Germany
2
Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Str. 35A, 38106 Braunschweig, Germany
3
Institute for Particle Technology (iPAT), Technische Universität Braunschweig, Volkmaroder Str. 5, 38104 Braunschweig, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Colin Hare and Anne Marie Healy
Pharmaceutics 2021, 13(7), 996; https://doi.org/10.3390/pharmaceutics13070996
Received: 23 April 2021 / Revised: 10 June 2021 / Accepted: 22 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Recent Advances in Secondary Processing of Pharmaceutical Powders)
In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in the planning phase and the implementation of digital twins in operation. The industrial processing of active pharmaceutical ingredients (APIs) into tablets requires the combination of discrete and continuous sub-processes with complex interdependencies regarding the material structures and characteristics. The API and excipients are mixed, granulated if required, and subsequently tableted. Thereby, the structure as well as the properties of the intermediate and final product are influenced by the raw materials, the parametrized processes and environmental conditions, which are subject to certain fluctuations. In this study, for the first time, an agent-based simulation model is presented, which enables the prediction, tracking, and tracing of resulting structures and properties of the intermediates of an industrial tableting process. Therefore, the methodology for the identification and development of product and process agents in an agent-based simulation is shown. Implemented physical models describe the impact of process parameters on material structures. The tablet production with a pilot scale rotary press is experimentally characterized to provide calibration and validation data. Finally, the simulation results, predicting the final structures, are compared to the experimental data. View Full-Text
Keywords: agent-based modeling and simulation; process modeling and simulation; tableting; product structures and characteristics agent-based modeling and simulation; process modeling and simulation; tableting; product structures and characteristics
Show Figures

Figure 1

MDPI and ACS Style

Martin, N.L.; Schomberg, A.K.; Finke, J.H.; Abraham, T.G.-m.; Kwade, A.; Herrmann, C. Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression. Pharmaceutics 2021, 13, 996. https://doi.org/10.3390/pharmaceutics13070996

AMA Style

Martin NL, Schomberg AK, Finke JH, Abraham TG-m, Kwade A, Herrmann C. Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression. Pharmaceutics. 2021; 13(7):996. https://doi.org/10.3390/pharmaceutics13070996

Chicago/Turabian Style

Martin, Niels L., Ann K. Schomberg, Jan H. Finke, Tim G.-m. Abraham, Arno Kwade, and Christoph Herrmann. 2021. "Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression" Pharmaceutics 13, no. 7: 996. https://doi.org/10.3390/pharmaceutics13070996

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop