Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.1.1. Dosage Forms
2.1.2. Mimicking Administration Modalities
2.1.3. Drug Content Determination
2.2. Statistical Analysis
3. Results
3.1. Quality of Spironolactone and Hydrochlorothiazide Compounded Forms
3.2. Accuracy of Administered Doses
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Batch 1 | Batch 2 | Batch 3 | Mean | |
---|---|---|---|---|
Hydrochlorothiazide | 5.91 ± 0.51 | 5.85 ± 0.57 | 6.11 ± 0.28 | 5.93 ± 0.44 |
Spironolactone | 6.35 ± 0.45 | 6.12 ± 0.51 | 5.75 ± 0.46 | 6.07 ± 0.47 |
Batch 1 | Batch 2 | Batch 3 | Mean | |
---|---|---|---|---|
Hydrochlorothiazide | 2.02 ± 0.04 | 1.96 ± 0,03 | 1.97 ± 0.08 | 1.98 ± 0.06 |
Spironolactone | 5.10 ± 0.04 | 5.35 ± 0.13 | 4.74 ± 0.13 | 5.06 ± 0.28 |
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Binson, G.; Sanchez, C.; Waton, K.; Chanat, A.; Di Maio, M.; Beuzit, K.; Dupuis, A. Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms. Pharmaceutics 2021, 13, 1014. https://doi.org/10.3390/pharmaceutics13071014
Binson G, Sanchez C, Waton K, Chanat A, Di Maio M, Beuzit K, Dupuis A. Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms. Pharmaceutics. 2021; 13(7):1014. https://doi.org/10.3390/pharmaceutics13071014
Chicago/Turabian StyleBinson, Guillaume, Cécile Sanchez, Karen Waton, Adeline Chanat, Massimo Di Maio, Karine Beuzit, and Antoine Dupuis. 2021. "Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms" Pharmaceutics 13, no. 7: 1014. https://doi.org/10.3390/pharmaceutics13071014
APA StyleBinson, G., Sanchez, C., Waton, K., Chanat, A., Di Maio, M., Beuzit, K., & Dupuis, A. (2021). Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms. Pharmaceutics, 13(7), 1014. https://doi.org/10.3390/pharmaceutics13071014