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Article

Functionality and Acceptance of the EsoCap System—A Novel Film-Based Drug Delivery Technology: Results of an In Vivo Study

1
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Straße 3, 17489 Greifswald, Germany
2
Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Laura Modica de Mohac and Dimitrios A. Lamprou
Pharmaceutics 2021, 13(6), 828; https://doi.org/10.3390/pharmaceutics13060828
Received: 14 May 2021 / Revised: 29 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021
(This article belongs to the Special Issue Advance in Development of Patient-Centric Dosage Form)
There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and acceptance of a novel modular drug delivery concept, called EsoCap system, by 12 healthy volunteers. For the first time, the EsoCap system enables targeted placement on the esophageal mucosa of a mucoadhesive polymer film. Acceptance was determined by means of a standardized questionnaire after administration and functionality of the device by MRI scans. Two different setups of the EsoCap system were tested: one setup with a density of 0.4 g/cm3 and one with a density of 1.0 g/cm3. Acceptability of the dosage form was also confirmed in addition to functionality, by measuring the applied film length. It was found that acceptance of the variant with the higher density was significantly better. This novel drug delivery technology could enable a targeted, local and long-lasting therapy of the esophagus for the first time, depending on the polymer film used. View Full-Text
Keywords: drug delivery; eosinophilic esophagitis; esophagus therapy; esophageal diseases; MRI study; ease of swallowing; user perspective drug delivery; eosinophilic esophagitis; esophagus therapy; esophageal diseases; MRI study; ease of swallowing; user perspective
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MDPI and ACS Style

Rosenbaum, C.; Grimm, M.; Krause, J.; Rump, A.; Kessler, R.; Hosten, N.; Weitschies, W. Functionality and Acceptance of the EsoCap System—A Novel Film-Based Drug Delivery Technology: Results of an In Vivo Study. Pharmaceutics 2021, 13, 828. https://doi.org/10.3390/pharmaceutics13060828

AMA Style

Rosenbaum C, Grimm M, Krause J, Rump A, Kessler R, Hosten N, Weitschies W. Functionality and Acceptance of the EsoCap System—A Novel Film-Based Drug Delivery Technology: Results of an In Vivo Study. Pharmaceutics. 2021; 13(6):828. https://doi.org/10.3390/pharmaceutics13060828

Chicago/Turabian Style

Rosenbaum, Christoph, Michael Grimm, Julius Krause, Adrian Rump, Rebecca Kessler, Norbert Hosten, and Werner Weitschies. 2021. "Functionality and Acceptance of the EsoCap System—A Novel Film-Based Drug Delivery Technology: Results of an In Vivo Study" Pharmaceutics 13, no. 6: 828. https://doi.org/10.3390/pharmaceutics13060828

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