Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Solutions
2.3. EHD-3D Printing
2.4. Characterization of Drug Patches
2.5. Drug Release Studies
2.6. Application of Drug Release Data to Mathematical Models
2.6.1. Zero Order Kinetics
2.6.2. First Order Kinetics
2.6.3. Higuchi Model
2.6.4. Korsmeyer–Peppas Model
2.7. Antibacterial Activity Assay
3. Results and Discussion
3.1. Characterization of Fabricated Samples
3.2. Drug Release and Mathematical Modeling of Release Mechanisms
3.3. Antibacterial Assessment of Fabricated Patches
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample Name (wt. ratio) | Viscosity (Pa.S) | Electrical Conductivity (µ.S cm−1) | Density (kg m−3) | Surface Tension (mN m−1) |
---|---|---|---|---|
BC/PCL (5:95) | 363 ± 0.5 | 1.20 ± 0.03 | 1445 ± 2 | 52.8 ± 0.1 |
BC/PCL (5:95) +AMX | 368 ± 0.3 | 1.20 ± 0.02 | 1448 ± 1 | 52.9 ± 0.1 |
BC/PCL (5:95) +AMP | 371 ± 0.1 | 1.20 ± 0.02 | 1452 ± 1 | 53.2 ± 0.5 |
BC/PCL (5:95) +KAN | 376 ± 0.2 | 1.20 ± 0.01 | 1459 ± 1 | 53.4 ± 0.3 |
Sample Name (wt. ratio) | Pore Size (µm2) | Porosity (%) |
---|---|---|
BC/PCL (5:95) | 2.22 ± 0.85 | 11.52 ± 1.14 |
BC/PCL (5:95) +AMX | 10.20 ± 0.35 | 32.43 ± 1.36 |
BC/PCL (5:95) +AMP | 6.18 ± 0.12 | 53.21 ± 1.76 |
BC/PCL (5:95) +KAN | 3.06 ± 1.09 | 19.11 ± 1.44 |
Sample Name (wt. ratio) | Yield (%) | Drug Loading (%) | Encapsulation Efficiency (%) |
---|---|---|---|
BC/PCL (5:95) | 98.4 ± 0.6 | - | - |
BC/PCL (5:95) +AMX | 98.2 ± 1.3 | 21.9 ± 0.3 | 97.4 ± 0.9 |
BC/PCL (5:95) +AMP | 96.3 ± 2.1 | 21.7 ± 0.7 | 96.8 ± 1.6 |
BC/PCL (5:95) +KAN | 97.9 ± 1.9 | 21.9 ± 0.5 | 98.6 ± 1.4 |
Sample | BC/PCL | BC/PCL+AMX | BC/PCL+AMP | BC/PCL+KAN | |
---|---|---|---|---|---|
Bacterial Strain | |||||
S. aureus | |||||
E. coli |
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Altun, E.; Yuca, E.; Ekren, N.; Kalaskar, D.M.; Ficai, D.; Dolete, G.; Ficai, A.; Gunduz, O. Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery. Pharmaceutics 2021, 13, 613. https://doi.org/10.3390/pharmaceutics13050613
Altun E, Yuca E, Ekren N, Kalaskar DM, Ficai D, Dolete G, Ficai A, Gunduz O. Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery. Pharmaceutics. 2021; 13(5):613. https://doi.org/10.3390/pharmaceutics13050613
Chicago/Turabian StyleAltun, Esra, Esra Yuca, Nazmi Ekren, Deepak M. Kalaskar, Denisa Ficai, Georgiana Dolete, Anton Ficai, and Oguzhan Gunduz. 2021. "Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery" Pharmaceutics 13, no. 5: 613. https://doi.org/10.3390/pharmaceutics13050613