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Open AccessArticle

In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers

1
Interdisciplinary Excellence Centre, Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös Street 6, H-6720 Szeged, Hungary
2
School of Engineering, Institute for Materials and Processes, The University of Edinburgh, King’s Buildings, Edinburgh EH9 3FB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Marcel Popa
Pharmaceutics 2021, 13(4), 556; https://doi.org/10.3390/pharmaceutics13040556
Received: 17 March 2021 / Revised: 9 April 2021 / Accepted: 12 April 2021 / Published: 15 April 2021
(This article belongs to the Special Issue Pharmaceutical Formulations with Antimicrobial Properties)
Nanofibers of the poorly water-soluble antibiotic ciprofloxacin (CIP) were fabricated in the form of an amorphous solid dispersion by using poly(vinyl pyrrolidone) as a polymer matrix, by the low-cost electrospinning method. The solubility of the nanofibers as well as their in vitro diffusion were remarkably higher than those of the CIP powder or the physical mixture of the two components. The fiber size and morphology were optimized, and it was found that the addition of the CIP to the electrospinning solution decreased the nanofiber diameter, leading to an increased specific surface area. Structural characterization confirmed the interactions between the drug and the polymer and the amorphous state of CIP inside the nanofibers. Since the solubility of CIP is pH-dependent, the in vitro solubility and dissolution studies were executed at different pH levels. The nanofiber sample with the finest morphology demonstrated a significant increase in solubility both in water and pH 7.4 buffer. Single medium and two-stage biorelevant dissolution studies were performed, and the release mechanism was described by mathematical models. Besides, in vitro diffusion from pH 6.8 to pH 7.4 notably increased when compared with the pure drug and physical mixture. Ciprofloxacin-loaded poly(vinyl pyrrolidone) (PVP) nanofibers can be considered as fast-dissolving formulations with improved physicochemical properties. View Full-Text
Keywords: amorphous solid dispersion; ciprofloxacin; electrospinning; nanofibers; poorly water-soluble drug; povidone amorphous solid dispersion; ciprofloxacin; electrospinning; nanofibers; poorly water-soluble drug; povidone
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MDPI and ACS Style

Uhljar, L.É.; Kan, S.Y.; Radacsi, N.; Koutsos, V.; Szabó-Révész, P.; Ambrus, R. In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers. Pharmaceutics 2021, 13, 556. https://doi.org/10.3390/pharmaceutics13040556

AMA Style

Uhljar LÉ, Kan SY, Radacsi N, Koutsos V, Szabó-Révész P, Ambrus R. In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers. Pharmaceutics. 2021; 13(4):556. https://doi.org/10.3390/pharmaceutics13040556

Chicago/Turabian Style

Uhljar, Luca É.; Kan, Sheng Y.; Radacsi, Norbert; Koutsos, Vasileios; Szabó-Révész, Piroska; Ambrus, Rita. 2021. "In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers" Pharmaceutics 13, no. 4: 556. https://doi.org/10.3390/pharmaceutics13040556

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