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Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management
 
 
Article

Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties

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Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska Ulica 8, SI-2000 Maribor, Slovenia
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Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska Ulica 8, SI-2000 Maribor, Slovenia
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Laboratory for Intelligent CAD Systems, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia
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IRNAS Ltd., Valvasorjeva 42, SI-2000 Maribor, Slovenia
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Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, AT-8010 Graz, Austria
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Laboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia
*
Authors to whom correspondence should be addressed.
Academic Editors: Patrizia Paolicelli and Maria Antonietta Casadei
Pharmaceutics 2021, 13(4), 564; https://doi.org/10.3390/pharmaceutics13040564
Received: 19 March 2021 / Revised: 8 April 2021 / Accepted: 11 April 2021 / Published: 16 April 2021
Despite the extensive utilization of polysaccharide hydrogels in regenerative medicine, current fabrication methods fail to produce mechanically stable scaffolds using only hydrogels. The recently developed hybrid extrusion-based bioprinting process promises to resolve these current issues by facilitating the simultaneous printing of stiff thermoplastic polymers and softer hydrogels at different temperatures. Using layer-by-layer deposition, mechanically advantageous scaffolds can be produced by integrating the softer hydrogel matrix into a stiffer synthetic framework. This work demonstrates the fabrication of hybrid hydrogel-thermoplastic polymer scaffolds with tunable structural and chemical properties for applications in tissue engineering and regenerative medicine. Through an alternating deposition of polycaprolactone and alginate/carboxymethylcellulose gel strands, scaffolds with the desired architecture (e.g., filament thickness, pore size, macro-/microporosity), and rheological characteristics (e.g., swelling capacity, degradation rate, and wettability) were prepared. The hybrid fabrication approach allows the fine-tuning of wettability (approx. 50–75°), swelling (approx. 0–20× increased mass), degradability (approx. 2–30+ days), and mechanical strength (approx. 0.2–11 MPa) in the range between pure hydrogels and pure thermoplastic polymers, while providing a gradient of surface properties and good biocompatibility. The controlled degradability and permeability of the hydrogel component may also enable controlled drug delivery. Our work shows that the novel hybrid hydrogel-thermoplastic scaffolds with adjustable characteristics have immense potential for tissue engineering and can serve as templates for developing novel wound dressings. View Full-Text
Keywords: 3D printing; wound dressings; alginate; carboxymethyl cellulose; polycaprolactone; polysaccharide-based scaffolds 3D printing; wound dressings; alginate; carboxymethyl cellulose; polycaprolactone; polysaccharide-based scaffolds
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MDPI and ACS Style

Milojević, M.; Harih, G.; Vihar, B.; Vajda, J.; Gradišnik, L.; Zidarič, T.; Stana Kleinschek, K.; Maver, U.; Maver, T. Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties. Pharmaceutics 2021, 13, 564. https://doi.org/10.3390/pharmaceutics13040564

AMA Style

Milojević M, Harih G, Vihar B, Vajda J, Gradišnik L, Zidarič T, Stana Kleinschek K, Maver U, Maver T. Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties. Pharmaceutics. 2021; 13(4):564. https://doi.org/10.3390/pharmaceutics13040564

Chicago/Turabian Style

Milojević, Marko, Gregor Harih, Boštjan Vihar, Jernej Vajda, Lidija Gradišnik, Tanja Zidarič, Karin Stana Kleinschek, Uroš Maver, and Tina Maver. 2021. "Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties" Pharmaceutics 13, no. 4: 564. https://doi.org/10.3390/pharmaceutics13040564

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