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Pharmaceutics
  • Correction
  • Open Access

2 December 2021

Correction: Mudie et al. In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets. Pharmaceutics 2021, 13, 1257

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Global Research & Development, Lonza, Bend, OR 97703, USA
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Author to whom correspondence should be addressed.
Current address: Pharmaceutics Department, University of Washington, Seattle, WA 98195, USA.
This article belongs to the Special Issue Solid Dispersions for Drug Delivery: Applications and Preparation Methods
The authors wish to make the following corrections to this paper [1].
There was an error in the original article in the Abstract section, where it was stated that the absolute average fold error (AAFE) of the in silico predictions for AUC0-inf for Calquence + famotidine was ≈3. A correction has been made to the abstract section: “In silico simulations of the HPMCAS-H ASD tablet and Calquence capsule provided good in vivo study prediction accuracy using a bottom–up approach (absolute average fold error of AUC0-inf < 2)”.
There was an error in the original article in the Results section (Section 3.6, paragraph 1), where it was stated that AAFE of the in silico predictions for AUC0-inf for the Calquence capsule + famotidine treatment was not <2. A correction has been made in the original article in the Results section (Section 3.6, paragraph 1): “The AAFE of the in silico predictions for AUC0-inf, Cmax, Tmax, and Cp versus time for all formulation treatments were <2-fold (ideal value = 1) with the exception of Cp versus time for the Calquence capsule + famotidine treatment, indicating that the in silico prediction framework is sufficient for simulating acalabrutinib blood plasma concentrations within this in vivo study”.
In the original article, there were mistakes in Table 4 as published, where AAFE for AUC0-inf for the Calquence capsule + pentagastrin was listed as 1.2 and AAFE for AUC0-inf for Calquence capsule + famotidine was listed as 3.6. The corrected Table 4 appears below.
Table 4. Noncompartmental analysis comparing simulated (sim) versus observed (obs) data for all formulation treatments in the dog study. Absolute average fold error (AAFE) was calculated for AUC0-inf, Cmax, Tmax, and Cp versus time to determine the accuracy of the in silico prediction exercise (ideal value = 1).
The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.

Reference

  1. Mudie, D.M.; Stewart, A.M.; Rosales, J.A.; Adam, M.S.; Morgen, M.M.; Vodak, D.T. In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets. Pharmaceutics 2021, 13, 1257. [Google Scholar] [CrossRef] [PubMed]
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