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Article

Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome

1
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei City 11031, Taiwan
2
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia
3
Department of Ophthalmology, Taipei Medical University Shuang Ho Hospital, New Taipei City 23561, Taiwan
4
Department of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan
5
College of Biomedical Engineering, Taipei Medical University, Taipei City 11031, Taiwan
6
College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan
7
Research Center of Biomedical Device, College of Biomedical Engineering, Taipei Medical University, Taipei City 11031, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Monica M. Jablonski
Pharmaceutics 2021, 13(11), 1801; https://doi.org/10.3390/pharmaceutics13111801
Received: 14 September 2021 / Revised: 6 October 2021 / Accepted: 22 October 2021 / Published: 27 October 2021
Dry eye syndrome (DES) is a common ophthalmological disease that decreases tear secretion and causes dryness, photophobia, pain, severe corneal rupture, and even blindness. Ocular and lacrimal gland inflammation is one of the pathological mechanisms underlying DES. Therefore, effective suppression of inflammation is a crucial strategy for the treatment of DES. Lutein, commonly found in healthy foods, has anti-inflammatory effects in corneal or retina-related cells and may be a potential therapy for DES. The addition of lutein to artificial tears (AT) as an eye-drop formulation for DES treatment in a mouse model was studied in the present work. Polyvinyl alcohol (PVA) was used as a thickener to increase the viscosity of eye drops to prolong drug retention on the ocular surface. A WST-8 assay in human corneal epithelial cells (HCE-2) showed that a concentration of <5 μM lutein (L5) and <1% PVA (P1) maintained the cell viability at 80%. A real-time PCR showed that the inflamed human corneal epithelial cells (HCECs) cocultured with L5P1 had downregulated expression of inflammatory genes such as IL-1β, IL-6, and TNF-α. In a benzalkonium chloride- (BAC) induced DES mouse model, AT/L5P1 could repair damaged corneas, elevate tear secretion, increase the number of goblet cells, and inhibit the production of inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the cornea. In conclusion, we demonstrate that lutein/PVA as eye drops could prolong the drug ocular retention time and effectively to decrease inflammation in DES mice. Therefore, lutein, obtained from eye drops, has a potential therapeutic role for DES. View Full-Text
Keywords: lutein; eye drops; dry eye syndrome; anti-inflammation; polyvinyl alcohol lutein; eye drops; dry eye syndrome; anti-inflammation; polyvinyl alcohol
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MDPI and ACS Style

Chen, Y.-Z.; Chen, Z.-Y.; Tang, Y.-J.; Tsai, C.-H.; Chuang, Y.-L.; Hsieh, E.-H.; Tucker, L.; Lin, I.-C.; Tseng, C.-L. Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome. Pharmaceutics 2021, 13, 1801. https://doi.org/10.3390/pharmaceutics13111801

AMA Style

Chen Y-Z, Chen Z-Y, Tang Y-J, Tsai C-H, Chuang Y-L, Hsieh E-H, Tucker L, Lin I-C, Tseng C-L. Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome. Pharmaceutics. 2021; 13(11):1801. https://doi.org/10.3390/pharmaceutics13111801

Chicago/Turabian Style

Chen, Yi-Zhou, Zhi-Yu Chen, Yu-Jun Tang, Cheng-Han Tsai, Yu-Lun Chuang, Erh-Hsuan Hsieh, Lachlan Tucker, I-Chan Lin, and Ching-Li Tseng. 2021. "Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome" Pharmaceutics 13, no. 11: 1801. https://doi.org/10.3390/pharmaceutics13111801

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