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Medical Applications of Metallic Bismuth Nanoparticles

Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (CNAM), HESAM Université, 2 Rue Conté, 75003 Paris, France
Service de Chimie Générale, Organique et Biomédicale, Laboratoire de RMN et d’Imagerie Moléculaire, Université de Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium
Author to whom correspondence should be addressed.
Academic Editors: Lionel Fernel Gamarra, Alexandre Malta Rossi, Joao Paulo Borges and Javier Bustamante Mamani
Pharmaceutics 2021, 13(11), 1793;
Received: 28 September 2021 / Revised: 19 October 2021 / Accepted: 20 October 2021 / Published: 26 October 2021
(This article belongs to the Special Issue Magnetic Nanoparticles for Therapy and Diagnosis in Nanomedicine)
Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the literature revealed the significant potential of metallic bismuth nanoparticles in different theranostic applications. In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy. The properties of these metallic bismuth nanoparticles as bactericidal, fungicidal, antiparasitic and antibiofilm agents have also been studied. Although information concerning the toxic effects of these nanoparticles has been collected, these data are insufficient when considering the immediate clinical use of these new nanoparticles. View Full-Text
Keywords: bismuth; nanoparticles; theranostic agents; biocompatibility bismuth; nanoparticles; theranostic agents; biocompatibility
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MDPI and ACS Style

Gomez, C.; Hallot, G.; Laurent, S.; Port, M. Medical Applications of Metallic Bismuth Nanoparticles. Pharmaceutics 2021, 13, 1793.

AMA Style

Gomez C, Hallot G, Laurent S, Port M. Medical Applications of Metallic Bismuth Nanoparticles. Pharmaceutics. 2021; 13(11):1793.

Chicago/Turabian Style

Gomez, Catherine, Gauthier Hallot, Sophie Laurent, and Marc Port. 2021. "Medical Applications of Metallic Bismuth Nanoparticles" Pharmaceutics 13, no. 11: 1793.

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