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Article

Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing

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Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary
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Doctoral School of Pharmaceutical Sciences, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary
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Department of Computer Graphics and Image Processing, Faculty of Informatics, University of Debrecen, Kassai út 26, H-4028 Debrecen, Hungary
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Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
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Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98, H-4032 Debrecen, Hungary
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Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary
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Department of Medical Microbiology, Faculty of Medicine and Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary
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Author to whom correspondence should be addressed.
Academic Editor: Istvan Antal
Pharmaceutics 2021, 13(10), 1714; https://doi.org/10.3390/pharmaceutics13101714
Received: 13 September 2021 / Revised: 7 October 2021 / Accepted: 12 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Advanced Drug Delivery Systems and Technology in Hungary)
Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of complex, personalized medications. 3D printing can be an excellent alternative instead of industrial manufacturing, which is complicated and time-consuming. In our work, the 3D printed vaginal rings were filled manually with jellified metronidazole or chloramphenicol for the treatment of bacterial vaginosis. The need for manual filling was certified by the thermogravimetric and heatflow assay results. The manufactured samples were analyzed by an Erweka USP type II Dissolution Apparatus, and the dissolution profile can be distinguished based on the applied jellifying agents and the API’s. All samples were considered non-similar based on the pairwise comparison. The biocompatibility properties were determined by prolonged MTT assay on HeLa cells, and the polymer could be considered non-toxic. Based on the microbiological assay on E. coli metronidazole and chitosan containing samples had bactericidal effects while just metronidazole or just chitosan containing samples bacteriostatic effect. None of these samples showed a fungistatic or fungicide effect against C. albicans. Based on our results, we successfully manufactured 3D printed vaginal rings filled with jellified metronidazole. View Full-Text
Keywords: personalized medication; vaginal ring; 3D printing; FDM; dissolution test; biocompatibility; MTT assay personalized medication; vaginal ring; 3D printing; FDM; dissolution test; biocompatibility; MTT assay
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MDPI and ACS Style

Arany, P.; Papp, I.; Zichar, M.; Regdon, G., Jr.; Béres, M.; Szalóki, M.; Kovács, R.; Fehér, P.; Ujhelyi, Z.; Vecsernyés, M.; Bácskay, I. Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing. Pharmaceutics 2021, 13, 1714. https://doi.org/10.3390/pharmaceutics13101714

AMA Style

Arany P, Papp I, Zichar M, Regdon G Jr., Béres M, Szalóki M, Kovács R, Fehér P, Ujhelyi Z, Vecsernyés M, Bácskay I. Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing. Pharmaceutics. 2021; 13(10):1714. https://doi.org/10.3390/pharmaceutics13101714

Chicago/Turabian Style

Arany, Petra, Ildikó Papp, Marianna Zichar, Géza Regdon Jr., Mónika Béres, Melinda Szalóki, Renátó Kovács, Pálma Fehér, Zoltán Ujhelyi, Miklós Vecsernyés, and Ildikó Bácskay. 2021. "Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing" Pharmaceutics 13, no. 10: 1714. https://doi.org/10.3390/pharmaceutics13101714

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