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Therapeutic Ophthalmic Lenses: A Review

Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(1), 36;
Received: 12 November 2020 / Revised: 9 December 2020 / Accepted: 17 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Recent Advances in Ophthalmic Drug Delivery)
An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field. View Full-Text
Keywords: therapeutic contact lenses; therapeutic intraocular lenses; eye diseases; glaucoma; cataract; corneal diseases; posterior segment of the eye diseases therapeutic contact lenses; therapeutic intraocular lenses; eye diseases; glaucoma; cataract; corneal diseases; posterior segment of the eye diseases
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MDPI and ACS Style

Toffoletto, N.; Saramago, B.; Serro, A.P. Therapeutic Ophthalmic Lenses: A Review. Pharmaceutics 2021, 13, 36.

AMA Style

Toffoletto N, Saramago B, Serro AP. Therapeutic Ophthalmic Lenses: A Review. Pharmaceutics. 2021; 13(1):36.

Chicago/Turabian Style

Toffoletto, Nadia, Benilde Saramago, and Ana Paula Serro. 2021. "Therapeutic Ophthalmic Lenses: A Review" Pharmaceutics 13, no. 1: 36.

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