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Review

Antibacterial Layer-by-Layer Coatings for Medical Implants

1
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182 C, 20014 Donostia-San Sebastian, Spain
2
Department of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2021, 13(1), 16; https://doi.org/10.3390/pharmaceutics13010016
Received: 20 November 2020 / Revised: 17 December 2020 / Accepted: 21 December 2020 / Published: 24 December 2020
(This article belongs to the Special Issue Local Antibacterial and Antimicrobial Drug Delivery Systems)
The widespread occurrence of nosocomial infections and the emergence of new bacterial strands calls for the development of antibacterial coatings with localized antibacterial action that are capable of facing the challenges posed by increasing bacterial resistance to antibiotics. The Layer-by-Layer (LbL) technique, based on the alternating assembly of oppositely charged polyelectrolytes, can be applied for the non-covalent modification of multiple substrates, including medical implants. Polyelectrolyte multilayers fabricated by the LbL technique have been extensively researched for the development of antibacterial coatings as they can be loaded with antibiotics, antibacterial peptides, nanoparticles with bactericide action, in addition to being capable of restricting adhesion of bacteria to surfaces. In this review, the different approaches that apply LbL for antibacterial coatings, emphasizing those that can be applied for implant modification are presented. View Full-Text
Keywords: bacterial infections; polyelectrolytes; Layer-by-Layer; antibacterial coatings; antiadhesive surfaces; localized action; medical implants bacterial infections; polyelectrolytes; Layer-by-Layer; antibacterial coatings; antiadhesive surfaces; localized action; medical implants
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MDPI and ACS Style

Escobar, A.; Muzzio, N.; Moya, S.E. Antibacterial Layer-by-Layer Coatings for Medical Implants. Pharmaceutics 2021, 13, 16. https://doi.org/10.3390/pharmaceutics13010016

AMA Style

Escobar A, Muzzio N, Moya SE. Antibacterial Layer-by-Layer Coatings for Medical Implants. Pharmaceutics. 2021; 13(1):16. https://doi.org/10.3390/pharmaceutics13010016

Chicago/Turabian Style

Escobar, Ane, Nicolas Muzzio, and Sergio E. Moya 2021. "Antibacterial Layer-by-Layer Coatings for Medical Implants" Pharmaceutics 13, no. 1: 16. https://doi.org/10.3390/pharmaceutics13010016

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