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Article

Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions

Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, 3000 Leuven, Belgium
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Pharmaceutics 2020, 12(9), 878; https://doi.org/10.3390/pharmaceutics12090878
Received: 11 August 2020 / Revised: 26 August 2020 / Accepted: 27 August 2020 / Published: 15 September 2020
The aim of this paper was to investigate whether a surface coating technique could be developed that can predict the phase behavior of amorphous solid dispersions (ASDs) coated on beads. ASDs of miconazole (MIC) and poly(vinylpyrrolidone-co-vinyl acetate) (PVP-VA) in methanol (MeOH) were studied as a model system. First, the low crystallization tendency of the model drug in MeOH was evaluated and confirmed. In a next step, a drug loading screening was performed on casted films and coated beads in order to define the highest possible MIC loading that still results in a one-phase amorphous system. These results indicate that film casting is not suitable for phase behavior predictions of ASDs coated on beads. Therefore, a setup for coating a solid surface was established inside the drying chamber of a spray dryer and it was found that this surface coating technique could predict the phase behavior of MIC-PVP-VA systems coated on beads, in case an intermittent spraying procedure is applied. Finally, spray drying was also evaluated for its ability to manufacture high drug-loaded ASDs. The highest possible drug loadings that still result in a one-phase amorphous system were obtained for bead coating and its predictive intermittent surface coating technique, followed by spray drying and finally by film casting and the continuous surface coating technique, thereby underlining the importance for further research into the underexplored bead coating process. View Full-Text
Keywords: bead coating; spray drying; film casting; surface coating bead coating; spray drying; film casting; surface coating
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MDPI and ACS Style

Boel, E.; Panini, P.; Van den Mooter, G. Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions. Pharmaceutics 2020, 12, 878. https://doi.org/10.3390/pharmaceutics12090878

AMA Style

Boel E, Panini P, Van den Mooter G. Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions. Pharmaceutics. 2020; 12(9):878. https://doi.org/10.3390/pharmaceutics12090878

Chicago/Turabian Style

Boel, Eline, Piyush Panini, and Guy Van den Mooter. 2020. "Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions" Pharmaceutics 12, no. 9: 878. https://doi.org/10.3390/pharmaceutics12090878

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