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Open AccessArticle

Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties

Department of Pharmaceutical Technology, Medical University of Gdansk, Hallera Str. 107, 80-416 Gdansk, Poland
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Pharmaceutics 2020, 12(3), 250; https://doi.org/10.3390/pharmaceutics12030250
Received: 7 February 2020 / Revised: 3 March 2020 / Accepted: 4 March 2020 / Published: 10 March 2020
(This article belongs to the Special Issue Paediatric Drug Delivery)
The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated with achieving a proper homogeneity and mechanical properties of the films. Hypromellose (HPMC) and a mixture of polyvinyl alcohol (AP) and povidone (PVP) were compared in terms of their suitability for ODFs incorporating suspended micronized loratadine (LO) in a concentration range of 10%–40%. In a planetary mixer (Thinky), a uniform dispersion of LO in an aqueous viscous casting solution was obtained. The suspended LO particles caused dose-dependent changes in the viscosity of the casting mass and affected the mechanical quality of ODFs. Drug concentrations higher than 30% reduced the film flexibility and tear resistance, depending on the polymer type. LO films with a thickness of 100 µm disintegrated within 60-100 s, with no significant influence of the LO content in the range 10%–30%. HPMC films, regardless of the drug concentration, met the pharmacopoeial requirements regarding the uniformity of the drug content. AP/PVP films were too elastic, and the drug content uniformity was not achieved. The conclusion is that, using an HPMC matrix, it is possible to obtain a high load of a poorly water-soluble drug (30% of dry film mass corresponds to a dose of 5 mg per 1.5 cm2) in ODFs characterized by proper physical characteristics. View Full-Text
Keywords: orodispersible film; suspension; loratadine; mechanical properties; viscosity; content uniformity orodispersible film; suspension; loratadine; mechanical properties; viscosity; content uniformity
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Centkowska, K.; Ławrecka, E.; Sznitowska, M. Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties. Pharmaceutics 2020, 12, 250.

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