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Open AccessArticle

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

1
Department of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy
2
Institute of Nanotechnology, National Research Council of Italy, c/o Department of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy
3
Institute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, Italy
4
Institute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 213; https://doi.org/10.3390/pharmaceutics12030213
Received: 8 January 2020 / Revised: 22 February 2020 / Accepted: 25 February 2020 / Published: 1 March 2020
(This article belongs to the Special Issue Coating Design: From Nanoparticle to Solid Dosage)
A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete. View Full-Text
Keywords: initiated chemical vapour deposition; drug delivery; poly(methyl methacrylate) (PMMA) copolymer; antibacterial test initiated chemical vapour deposition; drug delivery; poly(methyl methacrylate) (PMMA) copolymer; antibacterial test
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Decandia, G.; Palumbo, F.; Treglia, A.; Armenise, V.; Favia, P.; Baruzzi, F.; Unger, K.; Perrotta, A.; Coclite, A.M. Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery. Pharmaceutics 2020, 12, 213.

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