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Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects

1
Human resources for I+D+i Department, National Institute for Agricultural and Food Research and Technology, Ctra. de la Coruña (Autovía A6) Km. 7.5, 28040 Madrid, Spain
2
University of Alcalá, Ctra. de Madrid-Barcelona (Autovía A2) Km. 33,600, 28805 Alcalá de Henares, Madrid, Spain
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 94; https://doi.org/10.3390/pharmaceutics12020094
Received: 25 December 2019 / Revised: 17 January 2020 / Accepted: 22 January 2020 / Published: 24 January 2020
(This article belongs to the Special Issue Ophthalmic Drug Delivery)
Excitotoxicity seems to play a critical role in ocular neurodegeneration. Excess-glutamate-mediated retinal ganglion cells death is the principal cause of cell loss. Uncontrolled glutamate in the synapsis has significant implications in the pathogenesis of neurodegenerative disorders. The exploitation of various approaches of controlled release systems enhances the pharmacokinetic and pharmacodynamic activity of drugs. In particular, microparticles are secure, can maintain therapeutic drug concentrations in the eye for prolonged periods, and make intimate contact by improving drug bioavailability. According to the promising results reported, possible new investigations will focus intense attention on microparticulate formulations and can be expected to open the field to new alternatives for doctors, as currently required by patients. View Full-Text
Keywords: excitotoxicity; neurodegeneration; retina; microparticles; controlled drug release excitotoxicity; neurodegeneration; retina; microparticles; controlled drug release
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MDPI and ACS Style

Rodríguez Villanueva, J.; Martín Esteban, J.; Rodríguez Villanueva, L.J. Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects. Pharmaceutics 2020, 12, 94. https://doi.org/10.3390/pharmaceutics12020094

AMA Style

Rodríguez Villanueva J, Martín Esteban J, Rodríguez Villanueva LJ. Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects. Pharmaceutics. 2020; 12(2):94. https://doi.org/10.3390/pharmaceutics12020094

Chicago/Turabian Style

Rodríguez Villanueva, Javier; Martín Esteban, Jorge; Rodríguez Villanueva, Laura J. 2020. "Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects" Pharmaceutics 12, no. 2: 94. https://doi.org/10.3390/pharmaceutics12020094

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