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Open AccessArticle

Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

by Xiaojing Liu 1,†, Jingfu Jia 2,*,†, Shulei Duan 1, Xue Zhou 2, Anya Xiang 2, Ziling Lian 2 and Fahuan Ge 1,2,*
1
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2020, 12(2), 169; https://doi.org/10.3390/pharmaceutics12020169
Received: 3 January 2020 / Revised: 2 February 2020 / Accepted: 7 February 2020 / Published: 18 February 2020
Antimicrobial medicine and food packages based on bio-based film containing essential oils have attracted great attention worldwide. However, the controlled release of essential oils from these film nanocomposites is still a big challenge. In this study, a long-term antibacterial film nanocomposite composed of zein film and cinnamon essential oil (CEO) loaded MCM-41 silica nanoparticles was prepared. The CEO was loaded into MCM-41 particles via modified supercritical impregnation efficiently with a high drug load (>40 wt%). The morphologies of the prepared nanoparticles and film nanocomposite were characterized by a scanning electron microscope. The release behaviors of CEO under different temperatures, high humidity, continuous illumination and in phosphate buffer solution (PBS) solution were investigated. The results showed that the film nanocomposite had an outstanding release-control effect. The addition of MCM-41 nanoparticles also improved the mechanical properties of zein films. The antibacterial effect of CEO was significantly prolonged by the film nanocomposite; indicating the CEO film nanocomposite fabricated via modified supercritical CO2 impregnation was a potential long-term antibacterial medicine or food package material. View Full-Text
Keywords: film nanocomposite; essential oil; supercritical CO2; long-term package film nanocomposite; essential oil; supercritical CO2; long-term package
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MDPI and ACS Style

Liu, X.; Jia, J.; Duan, S.; Zhou, X.; Xiang, A.; Lian, Z.; Ge, F. Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging. Pharmaceutics 2020, 12, 169.

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