Brain and Nasal Cavity Anatomy of the Cynomolgus Monkey: Species Differences from the Viewpoint of Direct Delivery from the Nose to the Brain
, Akiko Tanaka 1 and Tomoyuki Furubayashi 1Round 1
Reviewer 1 Report
The manuscript is a concise but very clear and well-written presentation and discussion of the 3D structural characterization of the nasal cavity and brain of the cynomolgus monkey, focusing on the anatomic traits potentially influencing nose-to-brain drug delivery. It will be of interest to readers considering, performing or reading about intranasal delivery in this animal model, in order to a better extrapolation of results to humans.
Author Response
To Reviewer 1,
Thank you very much for the comment regarding our manuscript. The comment is very encouraging to us.
According to the Editor’s suggestion, the detail of the animal ethics was added to the manuscript (p.2, line 72).
Before revision;
The animal study was approved by the Animal Experiment Committee of New Drug Research Center, Inc. and conducted in accordance with relevant national legislation.
After revision;
The animal study (study No: 18905) was approved on October 24, 2018 by the Animal Care Council at New Drug Research Center, Inc. (approval No.: 181019A). The study was conducted in accordance with relevant national legislation.
Reviewer 2 Report
The paper is well written and gives information that can be useful in the choice of new animal models for the study of nose to brain delivery.
Author Response
To Reviewer 2,
Thank you very much for the comment regarding our manuscript. The comment is very encouraging to us.
According to the Editor’s suggestion, the detail of the animal ethics was added to the manuscript (p.2, line 72).
Before revision;
The animal study was approved by the Animal Experiment Committee of New Drug Research Center, Inc. and conducted in accordance with relevant national legislation.
After revision;
The animal study (study No: 18905) was approved on October 24, 2018 by the Animal Care Council at New Drug Research Center, Inc. (approval No.: 181019A). The study was conducted in accordance with relevant national legislation.
