Next Article in Journal
Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking
Next Article in Special Issue
Oral Delivery of Biologics via the Intestine
Previous Article in Journal
Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease
Previous Article in Special Issue
The Current Status of Clinical Research Involving Microneedles: A Systematic Review
Open AccessArticle

Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin

1
LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
2
Department of Pharmacy, University “G.d’Annunzio” Chieti-Pescara, 66013 Chieti, Italy
3
UCIBIO, REQUIMTE, MedTech, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(12), 1149; https://doi.org/10.3390/pharmaceutics12121149
Received: 5 November 2020 / Revised: 24 November 2020 / Accepted: 25 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue Non-invasive Drug Delivery Systems)
Nature has led to the discovery of biopolymers with noteworthy pharmaceutical applications. Blended biopolymers have demonstrated promising characteristics when compared with their individual counterparts. Sodium alginate (SA) is a marine polymer that has demonstrated the ability to form hydrogels, an interesting property for the development of cutaneous formulations. Predicting the good performance of blended biopolymers, a novel series of hybrid hydrogels based on SA and poly(vinyl) alcohol (PVA) were prepared. Quercetin, a natural polyphenolic flavonoid commonly found in fruits and vegetables, is widely known for its strong anti-inflammatory and antioxidant activity, thus with potential applications against melanoma, dermatitis, psoriasis, and skin ageing. Here, hydrogels were produced at different ratios of SA and PVA. The surface morphology, structure, interaction of polymers, the capacity to absorb water and the entrapment efficiency of quercetin were evaluated for the blended hydrogels. Targeting the cutaneous application of the formulations, the rheological properties of all unloaded and quercetin-loaded hydrogels revealed pseudoplastic behavior, evidence of non-thixotropy, good resistance to deformation, and profile maintenance with temperatures ranging from 20 °C up to 40 °C. The incorporation of quercetin in the hydrogel retained its antioxidant activity, confirmed by radical scavenging assays (ABTS and DPPH). The permeability of quercetin through the skin showed different penetration/permeation profiles according to the hydrogel’s blend. This behavior will allow the selection of SA-PVA at 2/1 ratio for a local and prolonged skin effect, making the use of these hydrogels a good solution to consider for the treatment of skin ageing and inflammation. View Full-Text
Keywords: antioxidant activity; isolated stratum corneum; PVPASC; poly(vinyl) alcohol; sodium alginate antioxidant activity; isolated stratum corneum; PVPASC; poly(vinyl) alcohol; sodium alginate
Show Figures

Graphical abstract

MDPI and ACS Style

Esposito, L.; Barbosa, A.I.; Moniz, T.; Costa Lima, S.; Costa, P.; Celia, C.; Reis, S. Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin. Pharmaceutics 2020, 12, 1149. https://doi.org/10.3390/pharmaceutics12121149

AMA Style

Esposito L, Barbosa AI, Moniz T, Costa Lima S, Costa P, Celia C, Reis S. Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin. Pharmaceutics. 2020; 12(12):1149. https://doi.org/10.3390/pharmaceutics12121149

Chicago/Turabian Style

Esposito, Ludovico; Barbosa, Ana I.; Moniz, Tânia; Costa Lima, Sofia; Costa, Paulo; Celia, Christian; Reis, Salette. 2020. "Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin" Pharmaceutics 12, no. 12: 1149. https://doi.org/10.3390/pharmaceutics12121149

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop