Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity
Abstract
:1. Introduction
2. Materials and Methods
2.1. Material
2.2. Preparation of the SDs
2.3. Characterization of the SDs
2.3.1. Fourier Transform Infrared Spectroscopy (FTIR)
2.3.2. Thermal Analysis
2.3.3. Powder X-ray Diffraction (PXRD)
2.3.4. Scanning Electronic Microscopy (SEM)
2.4. Antichagasic Activity
2.4.1. Parasite
2.4.2. In Vitro Antichagasic Evaluation
2.4.3. Statistical Analysis
3. Results and Discussion
3.1. Fourier Transform Infrared Spectroscopy (FTIR)
3.2. Differential Scanning Calorimetry (DSC)
3.3. Thermogravimetric Analysis (TG)
3.4. Powder X-ray Diffraction (PXRD)
3.5. Scanning Electron Microscopy (SEM)
3.6. In Vitro Antichagasic Activity
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Oliveira, V.d.S.; Dantas, E.D.; Queiroz, A.T.d.S.; Oliveira, J.W.d.F.; Silva, M.d.S.d.; Ferreira, P.G.; Siva, F.d.C.d.; Ferreira, V.F.; Lima, Á.A.N.d. Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity. Pharmaceutics 2020, 12, 1136. https://doi.org/10.3390/pharmaceutics12121136
Oliveira VdS, Dantas ED, Queiroz ATdS, Oliveira JWdF, Silva MdSd, Ferreira PG, Siva FdCd, Ferreira VF, Lima ÁANd. Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity. Pharmaceutics. 2020; 12(12):1136. https://doi.org/10.3390/pharmaceutics12121136
Chicago/Turabian StyleOliveira, Verônica da Silva, Elen Diana Dantas, Anna Thereza de Sousa Queiroz, Johny Wysllas de Freitas Oliveira, Marcelo de Sousa da Silva, Patricia Garcia Ferreira, Fernando de Carvalho da Siva, Vitor Francisco Ferreira, and Ádley Antonini Neves de Lima. 2020. "Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity" Pharmaceutics 12, no. 12: 1136. https://doi.org/10.3390/pharmaceutics12121136