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Review

Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

1
Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, Brazil
2
Department of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil
3
Department of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(10), 933; https://doi.org/10.3390/pharmaceutics12100933
Received: 17 September 2020 / Revised: 27 September 2020 / Accepted: 27 September 2020 / Published: 30 September 2020
This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications. View Full-Text
Keywords: solid dispersions; drug delivery; biological applications solid dispersions; drug delivery; biological applications
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MDPI and ACS Style

Oliveira, V.d.S.; de Almeida, A.S.; Albuquerque, I.d.S.; Duarte, F.Í.C.; Queiroz, B.C.S.H.; Converti, A.; Lima, Á.A.N.d. Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities. Pharmaceutics 2020, 12, 933. https://doi.org/10.3390/pharmaceutics12100933

AMA Style

Oliveira VdS, de Almeida AS, Albuquerque IdS, Duarte FÍC, Queiroz BCSH, Converti A, Lima ÁANd. Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities. Pharmaceutics. 2020; 12(10):933. https://doi.org/10.3390/pharmaceutics12100933

Chicago/Turabian Style

Oliveira, Verônica d.S., Amanda S. de Almeida, Ingrid d.S. Albuquerque, Fernanda Í.C. Duarte, Bárbara C.S.H. Queiroz, Attilio Converti, and Ádley A.N.d. Lima. 2020. "Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities" Pharmaceutics 12, no. 10: 933. https://doi.org/10.3390/pharmaceutics12100933

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