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Targeting the Choroid Plexuses for Protein Drug Delivery

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo: 304 Pharmacy Building, Buffalo, NY 14214, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Pharmaceutics 2020, 12(10), 963;
Received: 12 September 2020 / Revised: 5 October 2020 / Accepted: 10 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue New Drug Delivery across the Blood–Brain Barrier)
Delivery of therapeutic agents to the central nervous system is challenged by the barriers in place to regulate brain homeostasis. This is especially true for protein therapeutics. Targeting the barrier formed by the choroid plexuses at the interfaces of the systemic circulation and ventricular system may be a surrogate brain delivery strategy to circumvent the blood-brain barrier. Heterogenous cell populations located at the choroid plexuses provide diverse functions in regulating the exchange of material within the ventricular space. Receptor-mediated transcytosis may be a promising mechanism to deliver protein therapeutics across the tight junctions formed by choroid plexus epithelial cells. However, cerebrospinal fluid flow and other barriers formed by ependymal cells and perivascular spaces should also be considered for evaluation of protein therapeutic disposition. Various preclinical methods have been applied to delineate protein transport across the choroid plexuses, including imaging strategies, ventriculocisternal perfusions, and primary choroid plexus epithelial cell models. When used in combination with simultaneous measures of cerebrospinal fluid dynamics, they can yield important insight into pharmacokinetic properties within the brain. This review aims to provide an overview of the choroid plexuses and ventricular system to address their function as a barrier to pharmaceutical interventions and relevance for central nervous system drug delivery of protein therapeutics. Protein therapeutics targeting the ventricular system may provide new approaches in treating central nervous system diseases. View Full-Text
Keywords: choroid plexus; transcytosis; protein therapeutic choroid plexus; transcytosis; protein therapeutic
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MDPI and ACS Style

Bryniarski, M.A.; Ren, T.; Rizvi, A.R.; Snyder, A.M.; Morris, M.E. Targeting the Choroid Plexuses for Protein Drug Delivery. Pharmaceutics 2020, 12, 963.

AMA Style

Bryniarski MA, Ren T, Rizvi AR, Snyder AM, Morris ME. Targeting the Choroid Plexuses for Protein Drug Delivery. Pharmaceutics. 2020; 12(10):963.

Chicago/Turabian Style

Bryniarski, Mark A., Tianjing Ren, Abbas R. Rizvi, Anthony M. Snyder, and Marilyn E. Morris. 2020. "Targeting the Choroid Plexuses for Protein Drug Delivery" Pharmaceutics 12, no. 10: 963.

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