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Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Open AccessArticle

Patient-Centric Medicine Design: Key Characteristics of Oral Solid Dosage Forms that Improve Adherence and Acceptance in Older People

1
Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK
2
Colorcon Inc., Harleysville, PA 19438, USA
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(10), 905; https://doi.org/10.3390/pharmaceutics12100905
Received: 15 July 2020 / Revised: 18 September 2020 / Accepted: 21 September 2020 / Published: 23 September 2020
(This article belongs to the Special Issue Optimisation of Patient Centric Medicines for the Older Population)
Older people represent a very heterogeneous patient population and are the major user group of medication. Age-related changes mean that this population can encounter barriers towards taking medicines orally. The aim of this study was to investigate the characteristics of oral solid dosage forms that contribute to an age appropriate dosage design, with an aim to improve overall medication adherence and acceptance in older people. Fifty-two semistructured interviews were conducted with older people, informal (family) carers, and health and social care professionals. Formulation characteristics impacted three stages of the medication taking process: (1) medication identification and memorability, (2) medication handling and (3) swallowability. Small round tablets (≤7 mm) are least accepted amongst older people and their carers and had a negative impact on all stages. The use of bright, two-coloured preparations and interesting shapes improves identification and further aids memorability of indications and the timing of tablets. Palatability, while useful to enhance swallowability, also has an impact on the visual appeal and memorability of medication. Environmental, patient, medication and disease characteristics also determine preferences for formulation. Developing an age appropriate dosage design for older people, therefore, requires a holistic, patient-centric approach to improve adherence and acceptance. View Full-Text
Keywords: patient centric; oral solid; acceptance; adherence; older people patient centric; oral solid; acceptance; adherence; older people
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MDPI and ACS Style

Shariff, Z.; Kirby, D.; Missaghi, S.; Rajabi-Siahboomi, A.; Maidment, I. Patient-Centric Medicine Design: Key Characteristics of Oral Solid Dosage Forms that Improve Adherence and Acceptance in Older People. Pharmaceutics 2020, 12, 905.

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