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Open AccessArticle

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics

1
Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Catalonia, Spain
2
Neurovascular Research Laboratory, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Catalonia, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 16; https://doi.org/10.3390/pharmaceutics12010016
Received: 30 October 2019 / Revised: 2 December 2019 / Accepted: 17 December 2019 / Published: 21 December 2019
(This article belongs to the Special Issue PLGA Based Drug Carrier and Pharmaceutical Applications)
Developing multifunctional and biocompatible drug delivery nanoplatforms that integrate high drug loads and multiple imaging modalities avoiding cross-interferences is extremely challenging. Here we report on the successful chemical reaction of the high quantum yield biodegradable and photoluminescent polyester (BPLP) with the poly(lactic-co-glycolic acid) (PLGA) polymer to fabricate biocompatible photoluminescent nanocapsules (NCs). Furthermore, we transform the PLGA-BPLP NCs into a magnetic resonance (MR)/photoluminescence dual-modal imaging theranostic platform by incorporating superparamagnetic iron oxide nanoparticles (SPIONs) into the polymeric shell. In vitro phantoms confirmed the excellent MRI-r2 relaxivity values of the NCs whilst the cellular uptake of these NCs was clearly observed by fluorescence optical imaging. Besides, the NCs (mean size ~270 nm) were loaded with ~1 wt% of a model protein (BSA) and their PEGylation provided a more hydrophilic surface. The NCs show biocompatibility in vitro, as hCMEC/D3 endothelial cells viability was not affected for particle concentration up to 500 μg/mL. Interestingly, NCs decorated with SPIONs can be exploited for magnetic guiding and retention. View Full-Text
Keywords: PLGA nanocapsules; magnetic resonance imaging; photoluminescence; drug delivery systems; magnetic targeting; multimodal imaging; theranostics PLGA nanocapsules; magnetic resonance imaging; photoluminescence; drug delivery systems; magnetic targeting; multimodal imaging; theranostics
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MDPI and ACS Style

Zhang, Y.; García-Gabilondo, M.; Rosell, A.; Roig, A. MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics. Pharmaceutics 2020, 12, 16.

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