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Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods

Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea
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Pharmaceutics 2019, 11(9), 441; https://doi.org/10.3390/pharmaceutics11090441
Received: 9 July 2019 / Revised: 24 August 2019 / Accepted: 28 August 2019 / Published: 1 September 2019
(This article belongs to the Special Issue Recombinant Therapeutic Proteins for Drug Delivery)
The built-in innate immunity in the human body combats various diseases and their causative agents. One of the components of this system is Toll-like receptors (TLRs), which recognize structurally conserved molecules derived from microbes and/or endogenous molecules. Nonetheless, under certain conditions, these TLRs become hypofunctional or hyperfunctional, thus leading to a disease-like condition because their normal activity is compromised. In this regard, various small-molecule drugs and recombinant therapeutic proteins have been developed to treat the relevant diseases, such as rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, systemic lupus erythematosus, and allergy. Some drugs for these diseases have been clinically approved; however, their efficacy can be enhanced by conventional or targeted drug delivery systems. Certain delivery vehicles such as liposomes, hydrogels, nanoparticles, dendrimers, or cyclodextrins can be employed to enhance the targeted drug delivery. This review summarizes the TLR signaling pathway, associated diseases and their treatments, and the ways to efficiently deliver the drugs to a target site. View Full-Text
Keywords: Toll-like receptor; immunological disease; therapeutic; drug delivery method Toll-like receptor; immunological disease; therapeutic; drug delivery method
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MDPI and ACS Style

Javaid, N.; Yasmeen, F.; Choi, S. Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods. Pharmaceutics 2019, 11, 441.

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