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Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5001, Australia
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Pharmaceutics 2019, 11(7), 356; https://doi.org/10.3390/pharmaceutics11070356
Received: 21 June 2019 / Revised: 15 July 2019 / Accepted: 17 July 2019 / Published: 22 July 2019
(This article belongs to the Special Issue Designing Hydrogels for Controlled Drug Delivery)
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Abstract

Inulin-based hydrogels are useful carriers for the delivery of drugs in the colon-targeted system and in other biomedical applications. In this project, inulin hydrogels were fabricated by crosslinking oxidized inulin with adipic acid dihydrazide (AAD) without the use of a catalyst or initiator. The physicochemical properties of the obtained hydrogels were further characterized using different techniques, such as swelling experiments, in vitro drug release, degradation, and biocompatibility tests. The crosslinking was confirmed with Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). In vitro releases of 5-fluorouracil (5FU) from the various inulin hydrogels was enhanced in acidic conditions (pH 5) compared with physiological pH (pH 7.4). In addition, blank gels did not show any appreciable cytotoxicity, whereas 5FU-loaded hydrogels demonstrated efficacy against HCT116 colon cancer cells, which further confirms the potential use of these delivery platforms for direct targeting of 5-FU to the colon. View Full-Text
Keywords: hydrogels; oxidized inulin; periodate oxidation; colon targeting hydrogels; oxidized inulin; periodate oxidation; colon targeting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Afinjuomo, F.; Fouladian, P.; Parikh, A.; Barclay, T.G.; Song, Y.; Garg, S. Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery. Pharmaceutics 2019, 11, 356.

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