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Open AccessArticle

Supercritical Solvent Impregnation of Different Drugs in Mesoporous Nanostructured ZnO

Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy
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Pharmaceutics 2019, 11(7), 340; https://doi.org/10.3390/pharmaceutics11070340
Received: 28 May 2019 / Revised: 3 July 2019 / Accepted: 12 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Supercritical Fluid and Pharmaceutical Applications)
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Abstract

Supercritical solvent impregnation (SSI) is a green unconventional technique for preparing amorphous drug formulations. A mesoporous nanostructured ZnO (mesoNsZnO) carrier with 8-nm pores, spherical-nanoparticle morphology, and an SSA of 75 m2/g has been synthesized and, for the first time, subjected to SSI with poorly water-soluble drugs. Ibuprofen (IBU), clotrimazole (CTZ), and hydrocortisone (HC) were selected as highly, moderately, and poorly CO2-soluble drugs. Powder X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, nitrogen adsorption analysis, and ethanol extraction coupled with ultraviolet spectroscopy were employed to characterize the samples and quantify drug loading. Successful results were obtained with IBU and CTZ while HC loading was negligible, which could be related to different solubilities in CO2, drug size, and polarity. Successful SSI resulted in amorphous multilayer confinement of the drug. The mesoNsZnO-IBU system showed double drug loading than the mesoNsZnO-CTZ one, with a maximum uptake of 0.24 g/g. Variation of contact time during SSI of the mesoNsZnO-IBU system showed that drug loading triplicated between 3 and 8 h with an additional 30% increment between 8 h and 24 h. SSI did not affect the mesoNsZnO structure, and the presence of the adsorbed drug reduced the chemisorption of CO2 on the carrier surface. View Full-Text
Keywords: supercritical carbon dioxide; poorly water-soluble drugs; ibuprofen; clotrimazole; hydrocortisone; zinc oxide; drug adsorption; amorphization supercritical carbon dioxide; poorly water-soluble drugs; ibuprofen; clotrimazole; hydrocortisone; zinc oxide; drug adsorption; amorphization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Banchero, M.; Mohamed, S.S.Y.; Leone, F.; Lopez, F.; Ronchetti, S.; Manna, L.; Onida, B. Supercritical Solvent Impregnation of Different Drugs in Mesoporous Nanostructured ZnO. Pharmaceutics 2019, 11, 340.

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