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Open AccessArticle

Folic Acid-Functionalized Black Phosphorus Quantum Dots for Targeted Chemo-Photothermal Combination Cancer Therapy

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China
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Pharmaceutics 2019, 11(5), 242; https://doi.org/10.3390/pharmaceutics11050242
Received: 15 April 2019 / Revised: 11 May 2019 / Accepted: 17 May 2019 / Published: 21 May 2019
Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo- and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH- and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications. View Full-Text
Keywords: cancer targeted therapy; drug delivery; black phosphorus; quantum dots; photothermal therapy cancer targeted therapy; drug delivery; black phosphorus; quantum dots; photothermal therapy
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MDPI and ACS Style

Luo, M.; Cheng, W.; Zeng, X.; Mei, L.; Liu, G.; Deng, W. Folic Acid-Functionalized Black Phosphorus Quantum Dots for Targeted Chemo-Photothermal Combination Cancer Therapy. Pharmaceutics 2019, 11, 242.

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