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Open AccessArticle

Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder

1
Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21 000 Novi Sad, Serbia
2
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eotvos 6, 6720 Szeged, Hungary
3
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia
4
Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovica 8, 21 000 Novi Sad, Serbia
5
Department of Food Technology, Karlovac University of Applied Sciences, Josip Juraj Strossmayer Square 9, 47000 Karlovac, Croatia
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(10), 523; https://doi.org/10.3390/pharmaceutics11100523
Received: 9 August 2019 / Revised: 7 October 2019 / Accepted: 8 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Pharmaceutical Freeze Drying and Spray Drying)
White horehound (Marrubium vulgare L.), is a grey-leaved perennial herb, belonging to Lamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that M. vulgare has been used since ancient times in treating diverse diseases, it is only in the last decade or so that scientists have been able to lay the foundation for its potential pharmacological actions from the results observed through the prism of ethnopharmacological use of this species. The novelty of this study was that subcritical water extraction, acknowledged as a powerful extraction technology to recover phenolic compounds, was coupled with spray drying. The subcritical horehound extract, obtained using optimal process parameters, was used as a liquid feed in spray drying. Maltodextrin was used as a carrier in a concentration of 10%. Thus, two M. vulgare powders, carrier-free and 10% MD, were produced. Comprehensive powders characterization was conducted in order to evaluate their quality. Results confirmed that spray drying can be used as a method of choice for obtaining high quality horehound powders which kept the amorphous structure constant after 6 months. View Full-Text
Keywords: Marrubium vulgare; subcritical water extraction; spray drying; powder characterization Marrubium vulgare; subcritical water extraction; spray drying; powder characterization
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MDPI and ACS Style

Gavarić, A.; Vladić, J.; Ambrus, R.; Jokić, S.; Szabó-Révész, P.; Tomić, M.; Blažić, M.; Vidović, S. Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder. Pharmaceutics 2019, 11, 523.

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