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Pharmaceutics 2018, 10(4), 268; https://doi.org/10.3390/pharmaceutics10040268

Overview of DNA Self-Assembling: Progresses in Biomedical Applications

1
Coimbra Chemistry Centre (CQC), Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal
2
Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 22 November 2018 / Revised: 5 December 2018 / Accepted: 8 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Nanotheranostics and Cancer: Where Are We Now?)
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Abstract

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo. View Full-Text
Keywords: DNA self-assembling; gene delivery; drug delivery; protein delivery; theranostics; nanomedicine DNA self-assembling; gene delivery; drug delivery; protein delivery; theranostics; nanomedicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jorge, A.F.; Eritja, R. Overview of DNA Self-Assembling: Progresses in Biomedical Applications. Pharmaceutics 2018, 10, 268.

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