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Open AccessReview

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

College of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran
College of Pharmacy, Chung-Ang University, Seoul 06974, Korea
Authors to whom correspondence should be addressed.
Pharmaceutics 2018, 10(3), 131;
Received: 30 June 2018 / Revised: 10 August 2018 / Accepted: 13 August 2018 / Published: 17 August 2018
(This article belongs to the Special Issue Drug Metabolism, Pharmacokinetics and Bioanalysis)
Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein powders, choosing a suitable drying technique remains a challenge. In this review, the most frequent drying methods, such as freeze drying, spray drying, spray freeze drying, and supercritical fluid drying, for improving the stability and bioavailability of therapeutic proteins, are discussed. These technologies can prepare protein formulations for different applications as they produce particles with different sizes and morphologies. Proper drying methods are chosen, and the critical process parameters are optimized based on the proposed route of drug administration and the required pharmacokinetics. In an optimized drying procedure, the screening of formulations according to their protein properties is performed to prepare a stable protein formulation for various delivery systems, including pulmonary, nasal, and sustained-release applications. View Full-Text
Keywords: biopharmaceuticals; drying technology; protein stability; bioavailability; pharmacokinetics biopharmaceuticals; drying technology; protein stability; bioavailability; pharmacokinetics
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MDPI and ACS Style

Emami, F.; Vatanara, A.; Park, E.J.; Na, D.H. Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals. Pharmaceutics 2018, 10, 131.

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