Next Article in Journal
Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle
Next Article in Special Issue
Optimized Chitosan/Anion Polyelectrolyte Complex Based Inserts for Vaginal Delivery of Fluconazole: In Vitro/In Vivo Evaluation
Previous Article in Journal
A Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometric Assay for the Quantification of Fabry Disease Biomarker Globotriaosylceramide (GB3) in Fabry Model Mouse
Previous Article in Special Issue
Acyclovir-Loaded Chitosan Nanospheres from Nano-Emulsion Templating for the Topical Treatment of Herpesviruses Infections
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
Pharmaceutics 2018, 10(2), 70;

Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation

Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Japan
Department of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan
Nikkiso Co., Ltd., Ebisu, Shibuya-ku, Tokyo 150-6022, Japan
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 30 May 2018 / Accepted: 4 June 2018 / Published: 8 June 2018
(This article belongs to the Special Issue Chitosan Biomedical Applications: Opportunities and Challenges)
Full-Text   |   PDF [25021 KB, uploaded 8 June 2018]   |  


Burr holes in craniotomy are not self-repairing bone defects. To regenerate new bone at the sites of these defects, a good scaffold is required. Biodegradable hybrids including silica or siloxane networks have been investigated as bone tissue scaffolds. This study examined skull bone regeneration using chitosan-siloxane hybrids after long-term implantation (two and three years). After implantation of the hybrids, the surrounding cells migrated and formed fibrous tissues and blood vessels. Then, bone formation occurred from the surrounding blood vessels. Addition of calcium ions and coating with hydroxyapatite improved bone regeneration. Finally, the regenerated tissue area became smaller than the initial hole, and some areas changed to completed bone tissues. View Full-Text
Keywords: skull bone regeneration; chitosan-siloxane porous hybrid; long-term implantation skull bone regeneration; chitosan-siloxane porous hybrid; long-term implantation

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Shirosaki, Y.; Furuse, M.; Asano, T.; Kinoshita, Y.; Kuroiwa, T. Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation. Pharmaceutics 2018, 10, 70.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top