Next Article in Journal
Novel Fri1-like Viruses Infecting Acinetobacter baumannii—vB_AbaP_AS11 and vB_AbaP_AS12—Characterization, Comparative Genomic Analysis, and Host-Recognition Strategy.
Next Article in Special Issue
Integration of Human Papillomavirus Genomes in Head and Neck Cancer: Is It Time to Consider a Paradigm Shift?
Previous Article in Journal
Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses
Previous Article in Special Issue
Telomerase Induction in HPV Infection and Oncogenesis
Open AccessCommunication

Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis

Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany
*
Author to whom correspondence should be addressed.
Viruses 2017, 9(7), 187; https://doi.org/10.3390/v9070187
Received: 27 June 2017 / Revised: 7 July 2017 / Accepted: 7 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (βHPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of βHPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions. However, these assays failed to detect oncogenic functions of βHPV early proteins. They were not suitable for investigations aiming to study the interactive role of βHPV positive epidermis with mesenchymal cells and the extracellular matrix. This review focuses on βHPV gene functions with special focus on oncogenic mechanisms that may be relevant for skin cancer development. View Full-Text
Keywords: betapapillomavirus, extracellular matrix; invasion; cancer initiating cells; wound healing; squamous cell carcinoma betapapillomavirus, extracellular matrix; invasion; cancer initiating cells; wound healing; squamous cell carcinoma
Show Figures

Figure 1

MDPI and ACS Style

Hufbauer, M.; Akgül, B. Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis. Viruses 2017, 9, 187.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop