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Development of Polioencephalomyelitis in Cesarean-Derived Colostrum-Deprived Pigs Following Experimental Inoculation with Either Teschovirus A Serotype 2 or Serotype 11

Veterinary Diagnostic Laboratory, Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1850 Christensen Drive, Ames, IA 50011-1134, USA
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Academic Editor: Andrew Mehle
Viruses 2017, 9(7), 179; https://doi.org/10.3390/v9070179
Received: 15 May 2017 / Revised: 20 June 2017 / Accepted: 27 June 2017 / Published: 8 July 2017
(This article belongs to the Section Animal Viruses)
Teschovirus encephalomyelitis is a sporadic disease associated with Teschovirus A (PTV) serotype 1 and, less frequently, other serotypes. In recent years, the number of cases submitted to the Iowa State University Veterinary Diagnostic Laboratory with a history of posterior paresis has increased. Submission histories from various regions of the United States suggest a trend for clinical disease to persist in herds and affect a wider age-range of pigs than historically reported. Polioencephalitis and/or myelitis was consistently present and PTV was detected in affected neural tissue by PCR in a portion of cases. Sequencing from two clinical cases identified PTV-2 and PTV-11. To assess neuropathogenicity of these isolates, 5-week-old cesarean derived and colostrum-deprived pigs were assigned to three groups: negative control (n = 4), PTV-2-inoculated (n = 7), and PTV-11-inoculated (n = 7). Three PTV-2-inoculated pigs developed mild incoordination of the hind limbs, one of which progressed to posterior ataxia. While all PTV-11-inoculated pigs showed severe neurological signs consistent with Teschovirus encephalomyelitis, no evidences of neurological signs were observed in sham-inoculated animals. All PTV-2- and PTV-11-inoculated pigs had microscopic lesions consistent with Teschovirus encephalomyelitis. To our knowledge, this is the first description of PTV-11 and experimental study demonstrating the neuropathogenicity of PTV-11 in the United States. View Full-Text
Keywords: Teschovirus encephalomyelitis; Teschovirus A; Porcine teschovirus; Porcine teschovirus 2; Porcine teschovirus 11; poliomyelitis; Teschen disease; Talfan disease Teschovirus encephalomyelitis; Teschovirus A; Porcine teschovirus; Porcine teschovirus 2; Porcine teschovirus 11; poliomyelitis; Teschen disease; Talfan disease
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Matias Ferreyra, F.; Arruda, B.; Stevenson, G.; Schwartz, K.; Madson, D.; Yoon, K.-J.; Zhang, J.; Piñeyro, P.; Chen, Q.; Arruda, P. Development of Polioencephalomyelitis in Cesarean-Derived Colostrum-Deprived Pigs Following Experimental Inoculation with Either Teschovirus A Serotype 2 or Serotype 11. Viruses 2017, 9, 179.

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