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Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond

Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain
Nutrition and Food Safety Research Institute (INSA-UB), University of Barcelona, Santa Coloma de Gramenet 08921, Spain
Author to whom correspondence should be addressed.
Academic Editor: Stacey Schultz-Cherry
Viruses 2017, 9(2), 33;
Received: 29 November 2016 / Revised: 12 February 2017 / Accepted: 13 February 2017 / Published: 18 February 2017
(This article belongs to the Special Issue Astroviruses)
PDF [2599 KB, uploaded 18 February 2017]


Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease. View Full-Text
Keywords: astrovirus; zoonosis; gastroenteritis; encephalitis; meningitis; epidemiology astrovirus; zoonosis; gastroenteritis; encephalitis; meningitis; epidemiology

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Vu, D.-L.; Bosch, A.; Pintó, R.M.; Guix, S. Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond. Viruses 2017, 9, 33.

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