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Viruses 2017, 9(11), 323; https://doi.org/10.3390/v9110323

Protoparvovirus Interactions with the Cellular DNA Damage Response

Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Bond Life Sciences Center, Columbia, MO 65211, USA
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Received: 22 September 2017 / Revised: 16 October 2017 / Accepted: 23 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Protoparvoviruses: Friends or Foes?)
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Abstract

Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection. View Full-Text
Keywords: MVM; DNA damage response; cell cycle MVM; DNA damage response; cell cycle
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Majumder, K.; Etingov, I.; Pintel, D.J. Protoparvovirus Interactions with the Cellular DNA Damage Response. Viruses 2017, 9, 323.

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