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Viruses 2017, 9(11), 323;

Protoparvovirus Interactions with the Cellular DNA Damage Response

Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Bond Life Sciences Center, Columbia, MO 65211, USA
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 16 October 2017 / Accepted: 23 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Protoparvoviruses: Friends or Foes?)
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Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection. View Full-Text
Keywords: MVM; DNA damage response; cell cycle MVM; DNA damage response; cell cycle

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Majumder, K.; Etingov, I.; Pintel, D.J. Protoparvovirus Interactions with the Cellular DNA Damage Response. Viruses 2017, 9, 323.

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