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Virus Infection and Death Receptor-Mediated Apoptosis

Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2017, 9(11), 316;
Received: 21 September 2017 / Revised: 23 October 2017 / Accepted: 25 October 2017 / Published: 27 October 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host. Death receptor-mediated apoptosis plays an important role in viral pathogenesis and the host antiviral response. Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mainly by virally encoded gene products that suppress death receptor-mediated apoptosis. In this review, we summarize the current information on virus infection and death receptor-mediated apoptosis, particularly focusing on the viral proteins that modulate death receptor-mediated apoptosis. View Full-Text
Keywords: virus infection; death receptor; extrinsic apoptosis; host immune response virus infection; death receptor; extrinsic apoptosis; host immune response
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MDPI and ACS Style

Zhou, X.; Jiang, W.; Liu, Z.; Liu, S.; Liang, X. Virus Infection and Death Receptor-Mediated Apoptosis. Viruses 2017, 9, 316.

AMA Style

Zhou X, Jiang W, Liu Z, Liu S, Liang X. Virus Infection and Death Receptor-Mediated Apoptosis. Viruses. 2017; 9(11):316.

Chicago/Turabian Style

Zhou, Xingchen, Wenbo Jiang, Zhongshun Liu, Shuai Liu, and Xiaozhen Liang. 2017. "Virus Infection and Death Receptor-Mediated Apoptosis" Viruses 9, no. 11: 316.

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